Risk of transmission of herpesviruses through cord blood transplantation

Weinberg, Adriana, Enomoto, Laura, Li, Shaobing, Shen, Dingxia, Coll, Joseph and Shpall, Elizabeth J. (2005) Risk of transmission of herpesviruses through cord blood transplantation. Biology of Blood and Marrow Transplantation, 11 1: 35-38. doi:10.1016/j.bbmt.2004.09.005

Author Weinberg, Adriana
Enomoto, Laura
Li, Shaobing
Shen, Dingxia
Coll, Joseph
Shpall, Elizabeth J.
Title Risk of transmission of herpesviruses through cord blood transplantation
Journal name Biology of Blood and Marrow Transplantation   Check publisher's open access policy
ISSN 1083-8791
Publication date 2005-01
Sub-type Article (original research)
DOI 10.1016/j.bbmt.2004.09.005
Volume 11
Issue 1
Start page 35
End page 38
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract Cord blood (CB) progenitor cells are increasingly used for transplantation in children because of the lower risk of graft-versus-host disease compared with unrelated bone marrow and comparable rates of disease-free survival. There is concern that CB might carry a higher risk of opportunistic infections. Human herpesviruses (HHV) are common pathogens in transplant recipients. CB donors are routinely tested for the presence of anti-cytomegalovirus (CMV) immunoglobulin M to reduce the risk of collecting CMV-infected CB. To assess the incidence of β and γ HHV infection of CB collected under standard procedures, we tested 362 CB samples for the presence of CMV; HHV-6, -7, and -8; and Epstein-Barr virus DNA by polymerase chain reaction. HHV-6 DNA was found in 2 samples, yielding an incidence of 0.55% (95% confidence interval, 0.1%-2%). None of the other viral DNAs was found, resulting in a 95% confidence interval of 0% to 1% for the incidence of CMV, Epstein-Barr virus, HHV-7, and HHV-8. Because the seroprevalence of HHV-8 among the CB donors in this study was only 4%, these findings cannot be extended to HHV-8-endemic areas. Our data show that screening prospective CB donors with anti-CMV immunoglobulin M practically eliminates the risk of CB CMV transmission, but HHV-6 warrants CB testing by polymerase chain reaction.
Keyword Cord blood
Human herpesvirus-6
Epstein-barr virus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 02 Apr 2012, 14:48:15 EST by System User on behalf of School of Public Health