Estimation of lean body weight in older women with hip fracture

Mitchell, S. J., Hilmer, S. N., Kirkpatrick, C. M. J., Hansen, R. D., Williamson, D. A., Singh, N. A., Finnegan, T. P., Allen, B. J., Diamond, T. H., Diwan, A. D., Lloyd, B. D., Smith, E. U. R. and Singh, M. A. F. (2012) Estimation of lean body weight in older women with hip fracture. Journal of Nutrition Health and Aging, 16 2: 188-192. doi:10.1007/s12603-011-0100-y

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Author Mitchell, S. J.
Hilmer, S. N.
Kirkpatrick, C. M. J.
Hansen, R. D.
Williamson, D. A.
Singh, N. A.
Finnegan, T. P.
Allen, B. J.
Diamond, T. H.
Diwan, A. D.
Lloyd, B. D.
Smith, E. U. R.
Singh, M. A. F.
Total Author Count Override 13
Title Estimation of lean body weight in older women with hip fracture
Journal name Journal of Nutrition Health and Aging   Check publisher's open access policy
ISSN 1279-7707
1760-4788
Publication date 2012-02
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s12603-011-0100-y
Volume 16
Issue 2
Start page 188
End page 192
Total pages 5
Place of publication Paris, France
Publisher Editions SERDI
Collection year 2013
Language eng
Formatted abstract
Objective: Lean body weight (LBW) decreases with age while total body fat increases, resulting in altered drug pharmacokinetics. A semi-mechanistic equation estimating LBW using height, weight and sex has been developed for potential use across a wide range of body compositions. The aim of this study was to determine the ability of the LBW equation to estimate dual energy x-ray absorptiometry-derived fat free mass (FFMDXA) in a population of older women with recent hip fracture.
Methods: Baseline, four and 12 month data obtained from 23 women enrolled in the Sarcopenia and Hip Fracture study were pooled to give 58 measurements. LBW was estimated using the equation: LBW(kg)=9270Wt8780+(244BMI)
Body composition was classified as: ‘normal’ (BMI <25kg/m2 and not sarcopenic), ‘overweight-obese’ (BMI >25kg/m2 and not sarcopenic), ‘sarcopenic’ (sarcopenic and BMI <25kg/m2), or ‘sarcopenic-obese’ (sarcopenic and BMI >25kg/m2). The ability of the LBW equation to predict FFMDXA was determined graphically using Bland-Altman plots and quantitatively using the method of Sheiner and Beal.
Results: The mean ± SD age of female participants women was 83±7 years (n=23). Sarcopenia was frequently observed (65.2%). Bland-Altman plots demonstrated an underestimation by the LBW equation compared to FFMDXA. The bias (95% CI) and precision (95% CI) calculated using the method of Sheiner and Beal was 0.5kg (−0.7, 1.66kg) and 4.4kg (−3.7, 12.4kg) respectively for pooled data.
Conclusion: This equation can be used to easily calculate LBW. When compared to FFMDXA, the LBW equation resulted in a small underestimation on average in this population of women with recent hip fracture. The degree of bias may not be clinically important although further studies of larger heterogeneous cohorts are needed to investigate and potentially improve the accuracy of this predictive equation in larger clinical cohorts.
Keyword Lean body weight
Prediction
Ageing
Women
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Pharmacy Publications
 
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Created: Mon, 02 Apr 2012, 11:21:55 EST by System User on behalf of School of Pharmacy