Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?

Peatey, Christopher L., Leroy, Didier, Gardiner, Donald L. and Trenholme, Katherine R. (2012) Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?. Malaria Journal, 11 34: 34.1-34.4.


Author Peatey, Christopher L.
Leroy, Didier
Gardiner, Donald L.
Trenholme, Katherine R.
Title Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?
Formatted title Anti-malarial drugs: How effective are they against Plasmodium falciparum gametocytes?
Journal name Malaria Journal  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012-02-06
Sub-type Article
DOI 10.1186/1475-2875-11-34
Volume number 11
Issue number 34
ISSN 1475-2875
Start page 34.1
End page 34.4
Total pages 4
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract Background: Recent renewed emphasis on the eradication of malaria has highlighted the need for more tools with which to achieve this ambitious goal. One high priority area is the need to determine the gametocytocidal activity of both currently used anti-malarial drugs and those in the development pipeline. However, testing the activity of compounds against Plasmodium falciparum gametocytes is technically challenging both in vivo and in vitro.
Methods: Here the use of a simple robust assay to screen a panel of currently used and experimental anti-malarial drugs against mature P. falciparum gametocytes is described.
Results: Eight of 44 compounds tested reduced gametocyte viability by at least 50% and three showed IC50 values in nM range.
Conclusions: There is a need to identify new compounds with activity against late stage gametocytes and the information provided by this in vitro assay is a valuable first step, which can guide future clinical studies.
Keyword Plasmodium falciparum
Gametocyte
Anti-malarial drugs
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 34

 
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Created: Mon, 02 Apr 2012, 11:02:12 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences