Micronutrient Status in Children with Cerebral Palsy

Niikee Schoendorfer (2011). Micronutrient Status in Children with Cerebral Palsy PhD Thesis, School of Medicine, The University of Queensland.

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Author Niikee Schoendorfer
Thesis Title Micronutrient Status in Children with Cerebral Palsy
School, Centre or Institute School of Medicine
Institution The University of Queensland
Publication date 2011-09
Thesis type PhD Thesis
Supervisor PSW Davies
RN Boyd
L Vitetta
Total pages 163
Total colour pages 28
Total black and white pages 135
Language eng
Subjects 11 Medical and Health Sciences
111103 Nutritional Physiology
Abstract/Summary Micronutrients play a principal role in intermediary metabolism as cofactors in numerous enzymatic reactions or in non-enzymatic physiological functions such as in haematopoiesis. They also operate as antioxidants or immune system modulators, as well as being essential in cell proliferation and differentiation. Many micronutrients are essential for human nutrition, while deficiencies may arise if the need is high, intake or absorption is impaired or if excretion rates are increased. Adequate micronutrient levels may lead to improvements in immune function, inflammation and wound healing, catch up growth in children and lean body weight gain in adults, along with an improved psychological profile. The ability to be able to accurately detect and correct marginal depletions in both hospital patients and in more general populations may have significant public health implications. Their role in maintaining cellular homeostasis highlights a need for monitoring micronutrient adequacy, while their proper administration may have a substantial and measurable impact on nutritional adequacy, hospital costs and patient outcome. As limited data exists on micronutrient status in children with Cerebral Palsy (CP), the aims of this thesis were to evaluate micronutrient intake and functional biochemical parameters indicative of whole body nutritional status. Micronutrient status in children with marked forms of CP was explored and also whether percutaneous endoscopic gastronomy (PEG) tube supplemental feeding is adequate to maintain optimal physiological balance in these children. Micronutrient and antioxidant status, as well as other biochemical parameters were assessed in children with severe CP, whether orally or enterally fed, compared to typically developing children. All subjects were prepubescent boys and girls aged 4-12 years. Dietary intake duplicate samples were also analysed, including any supplemental feeds were applicable, for direct content of minerals, trace elements, energy and protein. Preliminary data led to further investigations involving methylation cycle capacity and protein adequacy, both of which revealed some interesting results. Overall these investigations highlighted the intricate workings of body biochemistry and the need for this to be adequately balanced, which calls for focus in these children to be expanded beyond the commonly held theories of nutrition relating mainly to energy intake and expenditure. This thesis will detail the findings of various investigations which have been reported in manuscripts, either under review, in press or published. It will conclude with a general discussion to integrate the most significant findings and also address the limitations of the studies detailed herein.
Keyword Severe Cerebral Palsy
Nutritional Biochemistry
Enteral Feeding
Micronutrient Status
Food Intakes
Mineral and Trace Elements
Competitive Nutrient Inhibition
Antioxidants and Oxidation
Enzyme Cofactors
Functional Assays
Methylation Cycle
One-carbon Metabolism
Methyl-folate Trap
Protein Recommendations
Additional Notes 1, 12, 13, 35, 36, 42, 43, 54, 69-74, 85-91, 135-137, 140, 143, 145, 147, 149, 155

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Created: Thu, 29 Mar 2012, 11:56:43 EST by Ms Niikee Schoendorfer on behalf of Library - Information Access Service