Use of talcum powder and endometrial cancer risk

Neill, Annette S., Nagle, Christina M., Spurdle, Amanda B. and Webb, Penelope M. (2012) Use of talcum powder and endometrial cancer risk. Cancer Causes and Control, 23 3: 513-519. doi:10.1007/s10552-011-9894-5

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Author Neill, Annette S.
Nagle, Christina M.
Spurdle, Amanda B.
Webb, Penelope M.
Title Use of talcum powder and endometrial cancer risk
Journal name Cancer Causes and Control   Check publisher's open access policy
ISSN 0957-5243
1573-7225
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1007/s10552-011-9894-5
Volume 23
Issue 3
Start page 513
End page 519
Total pages 7
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Collection year 2013
Language eng
Formatted abstract
Purpose:
Use of talcum powder in the perineal area has been associated with an increased risk of ovarian cancer, and a recent cohort study found a positive association with endometrial cancer. We sought to confirm this association using data from the Australian National Endometrial Cancer Study (ANECS).

Methods
:

ANECS was a population-based case-control study conducted from 2005 to 2007, in which 1,399 women with newly diagnosed histologically confirmed primary endometrial cancer and 740 control women provided risk factor information via telephone interview. Unconditional logistic regression was used to estimate odds ratios adjusting for potential confounders.

Results:

We found no significant association between ever use of talc in the perineal area (OR 0.88, 95% CI: 0.68-1.14) or upper body area (OR 0.90, 95% CI: 0.71-1.14) and risk of endometrial cancer. The results were similar when stratified by subtype. Composite variables combining frequency and duration of talc use were also not significantly associated with risk (any perineal area use p = 0.07 and any upper body use p = 0.49).

Conclusions:

The absence of any increase in risk and the similarity of our results for talc use on the upper body and in the perineal area do not support the hypothesis that use of talc in the perineal area is associated with an increased risk of endometrial cancer. Our data do not confirm the positive association between perineal talc use and endometrial cancer observed in the only previous study.
Keyword Endometrium
Carcinoma
Case-control studies
Talc
Risk factors
Epithelial Ovarian-Cancer
Perineal Use
Exposure
Inflammation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This study is conducted for the Australian National Endometrial Cancer Study Group.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
School of Medicine Publications
 
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