Astaxanthin in cardiovascular health and disease

Fassett, Robert G. and Coombes, Jeff S. (2012) Astaxanthin in cardiovascular health and disease. Molecules, 17 2: 2030-2048. doi:10.3390/molecules17022030

Author Fassett, Robert G.
Coombes, Jeff S.
Title Astaxanthin in cardiovascular health and disease
Journal name Molecules   Check publisher's open access policy
ISSN 1420-3049
Publication date 2012-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/molecules17022030
Open Access Status DOI
Volume 17
Issue 2
Start page 2030
End page 2048
Total pages 19
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2013
Language eng
Abstract Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes may reflect limitations in trial design, new, more potent antioxidant therapies are being pursued. Astaxanthin, a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail is one such agent. It has antioxidant and anti-inflammatory effects. Limited, short duration and small sample size studies have assessed the effects of astaxanthin on oxidative stress and inflammation biomarkers and have investigated bioavailability and safety. So far no significant adverse events have been observed and biomarkers of oxidative stress and inflammation are attenuated with astaxanthin supplementation. Experimental investigations in a range of species using a cardiac ischaemia-reperfusion model demonstrated cardiac muscle preservation when astaxanthin is administered either orally or intravenously prior to the induction of ischaemia. Human clinical cardiovascular studies using astaxanthin therapy have not yet been reported. On the basis of the promising results of experimental cardiovascular studies and the physicochemical and antioxidant properties and safety profile of astaxanthin, clinical trials should be undertaken.
Keyword Antioxidants
Marine carotenoids
Oxidative stress
Cardiovascular disease
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
ERA White List Items
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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