A limited sampling strategy for the simultaneous estimation of tacrolimus, mycophenolic acid and unbound prednisolone exposure in adult kidney transplant recipients

Barraclough, Katherine A., Isbel, Nicole M., Johnson, David W., Hawley, Carmel M., Lee, Katie J., Mcwhinney, Brett C., Ungerer, Jacobus P., Campbell, Scott B., Leary, Diana R. and Staatz, Christine E. (2012) A limited sampling strategy for the simultaneous estimation of tacrolimus, mycophenolic acid and unbound prednisolone exposure in adult kidney transplant recipients. Nephrology, 17 3: 294-299. doi:10.1111/j.1440-1797.2011.01560.x


Author Barraclough, Katherine A.
Isbel, Nicole M.
Johnson, David W.
Hawley, Carmel M.
Lee, Katie J.
Mcwhinney, Brett C.
Ungerer, Jacobus P.
Campbell, Scott B.
Leary, Diana R.
Staatz, Christine E.
Title A limited sampling strategy for the simultaneous estimation of tacrolimus, mycophenolic acid and unbound prednisolone exposure in adult kidney transplant recipients
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
1440-1797
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1111/j.1440-1797.2011.01560.x
Volume 17
Issue 3
Start page 294
End page 299
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing
Collection year 2013
Language eng
Formatted abstract Aim:
The aim of this study was to develop a limited sampling strategy (LSS) for the simultaneous estimation of exposure to tacrolimus, mycophenolic acid and unbound prednisolone in adult kidney transplant recipients.

Methods:
Tacrolimus, mycophenolic acid and unbound prednisolone area under the concentration-time curve profiles from 0 to 12 h post dose (AUC 0-12) were collected from 20 subjects. Multiple linear regression analyses were performed to develop a LSS enabling the simultaneous estimation of exposure to all three drugs. Median percentage prediction error and median absolute percentage prediction error were calculated via jackknife analysis to evaluate bias and imprecision.

Results:
LSS showed superior ability to predict exposure compared with single concentration-time points. A LSS incorporating concentration measurements at 0.5 h (C 0.5), 2 h (C 2) and 4 h (C 4) post dose displayed acceptable predictive ability for all three drugs.

Conclusion:
This LSS may serve as a useful research tool for further investigation of the utility of concentration monitoring of these medications. In this study, the authors have examined the predictive performance indices for three immunosuppressive drugs (tacrolimus, mycophenolic acid and prednisolone) using limited sampling at 0.5, 2 and 4 h post dose. Measurements for all three drugs demonstrated an acceptable predictive ability, making this strategy a potentially useful tool for future research studies.
Keyword Area under the concentration-time curve
Limited sampling strategy
Mycophenolic acid
Prednisolone
Tacrolimus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 81 Abstract Views  -  Detailed Statistics
Created: Mon, 26 Mar 2012, 12:04:09 EST by System User on behalf of Medicine - Princess Alexandra Hospital