Virus infection and allergy in the development of asthma: what is the connection?

Holt, Patrick G., Strickland, Deborah H. and Sly, Peter D. (2012) Virus infection and allergy in the development of asthma: what is the connection?. Current Opinion in Allergy and Clinical Immunology, 12 2: 151-157. doi:10.1097/ACI.0b013e3283520166


Author Holt, Patrick G.
Strickland, Deborah H.
Sly, Peter D.
Title Virus infection and allergy in the development of asthma: what is the connection?
Journal name Current Opinion in Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 1528-4050
1473-6322
Publication date 2012-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/ACI.0b013e3283520166
Volume 12
Issue 2
Start page 151
End page 157
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2013
Language eng
Formatted abstract Purpose of review: Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy, in both the cause and pathogenesis of atopic asthma. This review brings together the most recent publications relevant to this rapidly evolving area, particularly those focusing on underlying pathogenic mechanisms.
Recent findings: Salient findings from the recent literature include increased respiratory infection-associated symptom severity/duration and loss of asthma control in atopic relative to nonatopic children; up-regulation of Fc[epsilon]R1 expression on circulating monocytes/dendritic cells occurs during virus-associated atopic asthma exacerbations, providing a mechanism for transient amplification of underlying allergic airways inflammation; high potency of hRV-type C in induction of infection-associated wheeze; Th2-polarized immunity to mucosal dwelling bacteria and protection against asthma; a role for IL-15 in viral-associated airways inflammation; vitamin D and protection against infection-associated asthma exacerbations; strategies for reduction of infection-associated wheezing severity by boosting mucosal Treg cell activity via immunostimulation of the gut mucosa.
Summary: Research in this area is pointing towards new rationales for development of early intervention strategies for prevention of asthma initiation and progression in childhood, based on control of respiratory infections and/or sensitization to aeroallergens.
Keyword Atopic asthma
IgE receptor
Il-15
Virus Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Official 2013 Collection
 
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