Virus infection and allergy in the development of asthma: what is the connection?

Holt, Patrick G., Strickland, Deborah H. and Sly, Peter D. (2012) Virus infection and allergy in the development of asthma: what is the connection?. Current Opinion in Allergy and Clinical Immunology, 12 2: 151-157.


Author Holt, Patrick G.
Strickland, Deborah H.
Sly, Peter D.
Title Virus infection and allergy in the development of asthma: what is the connection?
Journal name Current Opinion in Allergy and Clinical Immunology  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2012-04
Sub-type Review of research - research literature review (NOT book review
DOI 10.1097/ACI.0b013e3283520166
Volume number 12
Issue number 2
ISSN 1528-4050; 1473-6322
Start page 151
End page 157
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Formatted abstract Purpose of review: Information is accumulating which implicates airway inflammation resulting from respiratory viral infections, acting against a background of atopy, in both the cause and pathogenesis of atopic asthma. This review brings together the most recent publications relevant to this rapidly evolving area, particularly those focusing on underlying pathogenic mechanisms.
Recent findings: Salient findings from the recent literature include increased respiratory infection-associated symptom severity/duration and loss of asthma control in atopic relative to nonatopic children; up-regulation of Fc[epsilon]R1 expression on circulating monocytes/dendritic cells occurs during virus-associated atopic asthma exacerbations, providing a mechanism for transient amplification of underlying allergic airways inflammation; high potency of hRV-type C in induction of infection-associated wheeze; Th2-polarized immunity to mucosal dwelling bacteria and protection against asthma; a role for IL-15 in viral-associated airways inflammation; vitamin D and protection against infection-associated asthma exacerbations; strategies for reduction of infection-associated wheezing severity by boosting mucosal Treg cell activity via immunostimulation of the gut mucosa.
Summary: Research in this area is pointing towards new rationales for development of early intervention strategies for prevention of asthma initiation and progression in childhood, based on control of respiratory infections and/or sensitization to aeroallergens.
Keyword Atopic asthma
IgE receptor
Il-15
Virus Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Review of research - research literature review (NOT book review
Collections: Official 2013 Collection
Admin only - QCMRI
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 22 Abstract Views  -  Detailed Statistics
Created: Mon, 26 Mar 2012, 03:23:19 EST by System User on behalf of Queensland Children's Medical Research Institute