The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance

Wang, David K., Varanasi, Srinivas, Hill, David J. T., Rasoul, Firas, Symons, Anne L. and Whittaker, Andrew K. (2012) The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance. Journal of Materials Chemistry, 22 14: 6994-7004. doi:10.1039/c2jm00039c


Author Wang, David K.
Varanasi, Srinivas
Hill, David J. T.
Rasoul, Firas
Symons, Anne L.
Whittaker, Andrew K.
Title The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance
Formatted title
The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2012-03-01
Sub-type Article (original research)
DOI 10.1039/c2jm00039c
Open Access Status Not Open Access
Volume 22
Issue 14
Start page 6994
End page 7004
Total pages 11
Place of publication Cambridge, U.K.
Publisher Royal Society of Chemistry
Collection year 2013
Language eng
Formatted abstract
Hydrogels based on segmented PLAaPEGbPLAa triblock copolymers have been extensively researched for biomedical applications, largely for drug delivery and tissue engineering applications, due in particular to the ability to tune their rate of degradation. By copolymerizing acrylated PLAaPEGbPLAa with acrylated Boltorn-PEG (BH20PEGA) macromonomer, the resulting hydrogels show enhanced swelling, and thus enhanced in vitro degradation profiles in PBS (pH 7.4) at 37 °C, compared to the hydrogels based on the triblock copolymers alone. The swelling ratios of the gels in water and in phosphate buffered saline solution, PBS, all decrease with increasing length of the PLA segment in the PLAaPEGbPLAa macromonomer and increase with increasing molecular weight of the PEG segment. The rates of mass loss of the hydrogels in PBS (pH 7.4) at 37 °C were higher for hydrogels with longer PLA segment length and higher PEG MW. Cytocompatibility studies confirm that the hydrogels are biocompatible and support the proliferation and attachment of periodontal fibroblasts.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 23 Mar 2012, 11:04:26 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology