Oseltamivir and early deterioration leading to death: A proportional mortality study for 2009A/H1N1 influenza

Hama, Rokuro, Jones, Mark, Okushima, Hiroki, Kitao, Masahiro, Noda, Narumi, Hayashi, Keiji and Sakaguchi, Keiko (2011) Oseltamivir and early deterioration leading to death: A proportional mortality study for 2009A/H1N1 influenza. The International Journal of Risk and Safety in Medicine, 23 4: 201-215. doi:10.3233/JRS-2011-0545


Author Hama, Rokuro
Jones, Mark
Okushima, Hiroki
Kitao, Masahiro
Noda, Narumi
Hayashi, Keiji
Sakaguchi, Keiko
Title Oseltamivir and early deterioration leading to death: A proportional mortality study for 2009A/H1N1 influenza
Journal name The International Journal of Risk and Safety in Medicine   Check publisher's open access policy
ISSN 0924-6479
1878-6847
Publication date 2011-01-01
Sub-type Article (original research)
DOI 10.3233/JRS-2011-0545
Volume 23
Issue 4
Start page 201
End page 215
Total pages 15
Place of publication Amsterdam, Netherlands
Publisher IOS Press
Collection year 2012
Language eng
Formatted abstract
Objective: To examine the epidemiological association between sudden deterioration leading to death and Tamiflu use.

Design: Proportional mortality study.

Setting: Japan.

Participants: 162 deaths without deterioration before the first consultation among all 198 deaths of mostly confirmed 2009A/H1N1 influenza.

Population at risk: Age-specific population of influenza patients prescribed Tamiflu and Relenza. Main outcome measure: Age-stratified pooled odds ratio (OR) for early (within 12 hours) deterioration and overall death of Tamiflu prescribed to Relenza prescribed patients.

Results: Of 119 deaths after Tamiflu was prescribed, 38 deteriorated within 12 hours (28 within 6 hours), while of 15 deaths after Relenza, none deteriorated within 12 hours. Pooled OR for early deterioration and overall death were 5.88 (95% CI: 1.30 to 26.6, p = 0.014) and 1.91 (p = 0.031) respectively. Baseline characteristics including risk factors did not contribute to early deterioration after Tamiflu use.

Conclusions: These data suggest Tamiflu use could induce sudden deterioration leading to death especially within 12 hours of prescription. These findings are consistent with sudden deaths observed in a series of animal toxicity studies, several reported case series and the results of prospective cohort studies. From “the precautionary principle” the potential harm of Tamiflu should be taken into account and further detailed studies should be conducted.
Keyword Oseltamivir
Sudden death
Adverse effect
Proportional mortality study
2009A/H1N1 influenza
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 22 Mar 2012, 21:48:04 EST by Geraldine Fitzgerald on behalf of School of Public Health