Acute dapsone overdose: The effects of continuous veno-venous haemofiltration on the elimination of dapsone

Masurkar, V. A., Edstein, M. D., Gorton, C. J. and Anstey, C. M. (2011) Acute dapsone overdose: The effects of continuous veno-venous haemofiltration on the elimination of dapsone. Anaesthesia and Intensive Care, 39 6: 1131-1135.

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Author Masurkar, V. A.
Edstein, M. D.
Gorton, C. J.
Anstey, C. M.
Title Acute dapsone overdose: The effects of continuous veno-venous haemofiltration on the elimination of dapsone
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2011-11
Sub-type Article (original research)
Volume 39
Issue 6
Start page 1131
End page 1135
Total pages 5
Place of publication Edgecliff, NSW, Australia
Publisher Australian Society of Anaesthetists
Collection year 2012
Language eng
Formatted abstract A 15-year-old girl presented after intentional ingestion of dapsone (7.2 g) and small quantities of azathioprine, methotrexate and prednisolone. The resulting methaemoglobinaemia and lactic acidosis persisted despite treatment with methylene blue, multiple-dose activated charcoal and ascorbic acid. Continuous veno-venous haemofiltration for 75 hours was used to treat the dapsone overdose. The patient’s serum dapsone concentrations were measured during and after continuous veno-venous haemofiltration. The rate of elimination of dapsone was over three times higher during, compared to after, continuous veno-venous haemofiltration. Continuous renal replacement therapy successfully reduced toxic dapsone concentrations in this patient with a good outcome.
Keyword Haemofiltration
Dapsone
Monoacetyldapsone
Pharmacokinetics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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