Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration

Singhania, Akul, Wu, Sherry Y. and McMillan, Nigel A. J. (2011) Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration. Journal of Drug Delivery, 2011 192562.1-192562.7. doi:10.1155/2011/192562

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Author Singhania, Akul
Wu, Sherry Y.
McMillan, Nigel A. J.
Title Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration
Journal name Journal of Drug Delivery   Check publisher's open access policy
ISSN 2090-3014
2090-3022
Publication date 2011
Sub-type Article (original research)
DOI 10.1155/2011/192562
Open Access Status DOI
Volume 2011
Start page 192562.1
End page 192562.7
Total pages 7
Editor Hsin-I Chang
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2012
Language eng
Abstract Intraperitoneal (i.p.) administration of small interfering RNA (siRNA) has, to date, shown promise in treating tumours located within the peritoneal cavity. The ability of these siRNA molecules to reach extraperitoneal tumours following i.p. administration is, however, yet to be investigated. Here, we examined the impact of PEGylation on the biodistribution of i.p. administered nucleic acids-containing lipoplexes. We showed that in contrast to non-PEGylated liposomes, PEGylated liposomes can deliver siRNA efficiently to extraperitoneal tumours following i.p. administration, resulting in a 45% reduction in tumour size when the oncogene-targeted siRNA was used. This difference was likely contributed by the decreased uptake of PEGylated lipoplexes in the first-pass organs, and, in particular, we observed a 10-fold decrease in the macrophage uptake of these particles compared to non-PEGylated counterparts. Overall, our results indicated the potential of using PEGylated liposomes to deliver siRNA for the treatment of i.p. localized cancer with coexisting extraperitoneal metastasis.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 20 Mar 2012, 15:47:43 EST by Kylie Hengst on behalf of UQ Diamantina Institute