Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Pimentel-Santos, Fernando M., Mourao, Ana Filipa, Ribeiro, Celia, Costa, Jose, Santos, Helena, Barcelos, Anabela, Pinto, Patricia, Godinho, Fatima, Cruz, Margarita, Vieira Sousa, Elsa, Santos, Rui Andre, Rabiais, Sara, Felix, Jorge, Fonseca, Joao Eurico, Guedes-Pinto, Henrico, Brown, Matthew A., Branco, Jaime C. and CORPOREA Study Group (2011) Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts. Clinical Rheumatology, 31 3: 447-454. doi:10.1007/s10067-011-1854-7


Author Pimentel-Santos, Fernando M.
Mourao, Ana Filipa
Ribeiro, Celia
Costa, Jose
Santos, Helena
Barcelos, Anabela
Pinto, Patricia
Godinho, Fatima
Cruz, Margarita
Vieira Sousa, Elsa
Santos, Rui Andre
Rabiais, Sara
Felix, Jorge
Fonseca, Joao Eurico
Guedes-Pinto, Henrico
Brown, Matthew A.
Branco, Jaime C.
CORPOREA Study Group
Title Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts
Journal name Clinical Rheumatology   Check publisher's open access policy
ISSN 0770-3198
1434-9949
Publication date 2011-10-19
Sub-type Article (original research)
DOI 10.1007/s10067-011-1854-7
Volume 31
Issue 3
Start page 447
End page 454
Total pages 8
Place of publication Surrey, United Kingdom
Publisher Springer
Collection year 2012
Language eng
Formatted abstract
The availability of population-specific normative data regarding disease severity measures is essential for patient assessment. The goals of the current study were to characterize the pattern of ankylosing spondylitis (AS) in Portuguese patients and to develop reference centile charts for BASDAI, BASFI, BASMI and mSASSS, the most widely used assessment tools in AS. AS cases were recruited from hospital outpatient clinics, with AS defined according to the modified New York criteria. Demographic and clinical data were recorded. All radiographs were evaluated by two independent experienced readers. Centile charts for BASDAI, BASFI, BASMI and mSASSS were constructed for both genders, using generalized linear models and regression models with duration of disease as independent variable. A total of 369 patients (62.3% male, mean ± (SD) age 45.4 ± 13.2 years, mean ± (SD) disease duration 11.4 ± 10.5 years, 70.7% B27-positive) were included. Family history of AS in a first-degree relative was reported in 17.6% of the cases. Regarding clinical disease pattern, at the time of assessment 42.3% had axial disease, 2.4% peripheral disease, 40.9% mixed disease and 7.1% isolated enthesopatic disease. Anterior uveitis (33.6%) was the most common extra-articular manifestation. The centile charts suggest that females reported greater disease activity and more functional impairment than males but had lower BASMI and mSASSS scores. Data collected through this study provided a demographic and clinical profile of patients with AS in Portugal. The development of centile charts constitutes a useful tool to assess the change of disease pattern over time and in response to therapeutic interventions.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 19 October 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 20 Mar 2012, 12:43:22 EST by Kylie Hengst on behalf of UQ Diamantina Institute