Tubular breast carcinoma: An argument against treatment de-escalation

Hansen, Carmen J., Kenny, Liz, Lakhani, Sunil R., Ung, Owen, Keller, Jacqui, Tripcony, Lee, Cheuk, Robyn, Grogan, Michelle, Vargas, Ana Cristina and Martin, Jarad (2012) Tubular breast carcinoma: An argument against treatment de-escalation. Journal of Medical Imaging and Radiation Oncology, 56 1: 116-122. doi:10.1111/j.1754-9485.2011.02330.x

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Author Hansen, Carmen J.
Kenny, Liz
Lakhani, Sunil R.
Ung, Owen
Keller, Jacqui
Tripcony, Lee
Cheuk, Robyn
Grogan, Michelle
Vargas, Ana Cristina
Martin, Jarad
Title Tubular breast carcinoma: An argument against treatment de-escalation
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
1754-9485
Publication date 2012-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1754-9485.2011.02330.x
Volume 56
Issue 1
Start page 116
End page 122
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2013
Language eng
Formatted abstract
Purpose:
To evaluate the role of adjuvant radiotherapy in management of patients with tubular carcinoma of the breast.

Methods:
One hundred seventy-eight patients treated for tubular carcinoma were identified from the Queensland Radium Institute database. A retrospective review of medical records identified 115 patients meeting eligibility criteria: breast-conserving surgery for a histological diagnosis of tubular carcinoma, minimum follow up of 12 months and adequate medical records.

Results:
Median follow up was 64 months. There were no significant differences between patient characteristics treated with and without radiotherapy. Median age at diagnosis was 54 (36-78) years. Ninety-five percent tumours were T1 and four patients had positive axillary lymph nodes. Of 94 patients treated with adjuvant radiotherapy, one developed local relapse. Five of 21 patients who did not have adjuvant radiotherapy failed locally. Five-year relapse-free survival with and without radiotherapy was 100 and 89%, respectively (hazard ratio for radiotherapy: 0.06; 95% confidence interval 0.01-0.32, P = 0.001).

Conclusion:
Radiotherapy has a significant impact on relapse-free survival in patients treated with breast-conserving surgery for tubular carcinoma.
Keyword Adenocarcinoma
Breast neoplasm
Radiotherapy
Radiotherapy
Adjuvant
Sentinel lymph node biopsy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 17 February 2012.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2013 Collection
School of Medicine Publications
 
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