Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen

Ruutu, Merja P., Chen, Xianfeng, Joshi, Ojas, Kendall, Mark A. and Frazer, Ian H. (2011) Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen. Experimental Dermatology, 20 6: 534-536. doi:10.1111/j.1600-0625.2010.01234.x

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Author Ruutu, Merja P.
Chen, Xianfeng
Joshi, Ojas
Kendall, Mark A.
Frazer, Ian H.
Title Increasing mechanical stimulus induces migration of Langerhans cells and impairs the immune response to intracutaneously delivered antigen
Journal name Experimental Dermatology   Check publisher's open access policy
ISSN 0906-6705
1600-0625
Publication date 2011-06
Sub-type Article (original research)
DOI 10.1111/j.1600-0625.2010.01234.x
Open Access Status File (Author Post-print)
Volume 20
Issue 6
Start page 534
End page 536
Total pages 3
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Abstract Skin is subjected regularly to mechanical stimulus. Surprisingly, when studying the use of microneedle arrays to introduce antigen into skin, we observed that mechanical stimulus to skin achieved by application of the arrays or a flat metal plate resulted in temporary depletion of Langerhans cells, with the degree of depletion related to the applied stress, whereas no depletion was seen in the interspersed dendritic epidermal T cell population. Further, a significantly impaired immune response to intracutaneous antigen administration was observed in skin recently subjected to mechanical stimulus. This observation may have implications for selection of sites of skin immunisation and for immunogenicity of infections at skin sites routinely subjected to mechanical stimuli.
Keyword Immune function
Langerhans cells
Mechanical stimulus
Pressure
Skin
Stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 20 Mar 2012, 11:23:55 EST by Kylie Hengst on behalf of UQ Diamantina Institute