Inhibition of melanization by a parasitoid serine protease homolog venom protein requires both the clip and the non-catalytic protease-like domains

Thomas, Pune and Asgari, Sassan (2011) Inhibition of melanization by a parasitoid serine protease homolog venom protein requires both the clip and the non-catalytic protease-like domains. Insects, 2 4: 509-514. doi:10.3390/insects2040509

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Author Thomas, Pune
Asgari, Sassan
Title Inhibition of melanization by a parasitoid serine protease homolog venom protein requires both the clip and the non-catalytic protease-like domains
Journal name Insects   Check publisher's open access policy
ISSN 2075-4450
Publication date 2011-11
Sub-type Article (original research)
DOI 10.3390/insects2040509
Open Access Status DOI
Volume 2
Issue 4
Start page 509
End page 514
Total pages 6
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2012
Language eng
Formatted abstract
Endoparasitoid wasps inject a variety of components into their host hemocoel at oviposition to facilitate successful development of their progeny. Among these are venom proteins which have been shown to play crucial roles in host regulation. A serine protease homolog (SPH)-like venom protein from Cotesia rubecula was previously shown to inhibit melanization in the host hemolymph by blocking activation of prophenoloxidase to phenoloxidase, a key enzyme in melanin formation. Similar to other SPHs, Vn50 consists of a clip and a protease-like (SPL) domain. Protein modeling demonstrated that Vn50 has a very similar structure to known SPHs and functional analysis of Vn50 domains expressed in insect cells indicated that neither of the domains on its own has an inhibitory effect on melanization.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
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Created: Mon, 19 Mar 2012, 17:57:55 EST by Gail Walter on behalf of School of Biological Sciences