Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4

Rohde, Holger, Qin, Junjie, Cui, Yujun, Li, Dongfang, Loman, Nicholas J., Hentschke, Moritz, Chen, Wentong, Pu, Fei, Peng, Yangqing, Li, Junua, Xi, Feng, Li, Shenghui, Li, Yin, Zhang, Zhaoxi, Yang, Xianwei, Zhao, Meiru, Wang, Peng, Guan, Yuanlin, Cen, Zhong, Zhao, Xiangna, Christner, Martin, Kobbe, Robin, Loos, Sebastian, Oh, Jun, Yang, Liang, Danchin, Antoine, Gao, George F., Song, Yajun, Li, Yingrui, Yang, Huanming, Wang, Jian, Xu, Jianguo, Pallen, Mark J., Wang, Jun, Aepfelbacher, Martin, Yang, Ruifu, The E. coli O104:H4 Genome Analysis Crowd-Sourcing Consortium and Petty, Nico (2011) Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. New England Journal of Medicine, 365 8: 718-724. doi:10.1056/NEJMoa1107643

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Author Rohde, Holger
Qin, Junjie
Cui, Yujun
Li, Dongfang
Loman, Nicholas J.
Hentschke, Moritz
Chen, Wentong
Pu, Fei
Peng, Yangqing
Li, Junua
Xi, Feng
Li, Shenghui
Li, Yin
Zhang, Zhaoxi
Yang, Xianwei
Zhao, Meiru
Wang, Peng
Guan, Yuanlin
Cen, Zhong
Zhao, Xiangna
Christner, Martin
Kobbe, Robin
Loos, Sebastian
Oh, Jun
Yang, Liang
Danchin, Antoine
Gao, George F.
Song, Yajun
Li, Yingrui
Yang, Huanming
Wang, Jian
Xu, Jianguo
Pallen, Mark J.
Wang, Jun
Aepfelbacher, Martin
Yang, Ruifu
The E. coli O104:H4 Genome Analysis Crowd-Sourcing Consortium
Petty, Nico
Title Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4
Formatted title
Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793; 533-4406
Publication date 2011-08-25
Sub-type Article (original research)
DOI 10.1056/NEJMoa1107643
Volume 365
Issue 8
Start page 718
End page 724
Total pages 7
Place of publication Boston, MA, United States
Publisher Massachusetts Medical Society
Collection year 2012
Language eng
Formatted abstract
An outbreak caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
Keyword Enteroaggregative escherichia-coli
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes "Brief report"

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 222 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 244 times in Scopus Article | Citations
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Created: Fri, 16 Mar 2012, 12:07:34 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences