Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system

Belov, Katherine, Sanderson, Claire E., Deakin, Janine E., Wong, Emily S. W., Assange, Daniel, McColl, Kaighin A., Gout, Alex, de Bono, Bernard, Barrow, Alexander D., Speed, Terence P., Trowsdale, John and Papenfuss, Anthony T. (2007) Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. Genome Research, 17 7: 982-991. doi:10.1101/gr.6121807


Author Belov, Katherine
Sanderson, Claire E.
Deakin, Janine E.
Wong, Emily S. W.
Assange, Daniel
McColl, Kaighin A.
Gout, Alex
de Bono, Bernard
Barrow, Alexander D.
Speed, Terence P.
Trowsdale, John
Papenfuss, Anthony T.
Title Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
1549-5469
Publication date 2007-07
Sub-type Article (original research)
DOI 10.1101/gr.6121807
Open Access Status DOI
Volume 17
Issue 7
Start page 982
End page 991
Total pages 10
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Language eng
Formatted abstract
The availability of the first marsupial genome sequence has allowed us to characterize the immunome of the gray short-tailed opossum (Monodelphis domestica). Here we report the identification of key immune genes, including the
highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors. It appears that the increase in complexity of the mammalian immune system occurred prior to the divergence of the marsupial and eutherian lineages ∼180 million years ago. Genomes of ancestral mammals most likely contained all of the key mammalian immune gene families, with evolution on different continents, in the presence of different pathogens leading to lineage specific expansions and contractions, resulting in some minor differences in gene number and composition
between different mammalian lineages. Gene expansion and extensive heterogeneity in opossum antimicrobial peptide genes may have evolved as a consequence of the newborn young needing to survive without an adaptive immune system in a pathogen laden environment. Given the similarities in the genomic architecture of the marsupial and eutherian immune systems, we propose that marsupials are ideal model  organisms for the study of developmental immunology.
Keyword MAJOR HISTOCOMPATIBILITY COMPLEX
MHC CLASS-I
MARSUPIAL MONODELPHIS-DOMESTICA
LEUKOCYTE RECEPTOR COMPLEX
ANCESTRAL REGION
GENE CLUSTERS
CHICKEN
FAMILY
DIVERSIFICATION
IDENTIFICATION
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 61 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 63 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 14 Mar 2012, 15:38:19 EST by Susan Allen on behalf of Institute for Molecular Bioscience