Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

Delaney, Andrew J., Power, John M. and Sah, Pankaj (2012) Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. Journal of Neurophysiology, 107 6: 1571-1575. doi:10.1152/jn.01066.2011


Author Delaney, Andrew J.
Power, John M.
Sah, Pankaj
Title Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
1522-1598
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.1152/jn.01066.2011
Open Access Status DOI
Volume 107
Issue 6
Start page 1571
End page 1575
Total pages 5
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2012
Language eng
Formatted abstract
Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltageactivated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC50 of ~10 µM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.
Keyword GluN2B
Memory
NMDA
P-type calcium channel
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print December 28, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
 
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Created: Wed, 14 Mar 2012, 14:22:21 EST by Debra McMurtrie on behalf of Queensland Brain Institute