Fatigue, depression, and health-related quality of life in patients with multiple sclerosis in Isfahan, Iran

Kargarfard, M., Eetemadifar, M., Mehrabi, M., Maghzi, A. H. and Hayatbakhsh, M. R. (2012) Fatigue, depression, and health-related quality of life in patients with multiple sclerosis in Isfahan, Iran. European Journal of Neurology, 19 3: 431-437. doi:10.1111/j.1468-1331.2011.03535.x


Author Kargarfard, M.
Eetemadifar, M.
Mehrabi, M.
Maghzi, A. H.
Hayatbakhsh, M. R.
Title Fatigue, depression, and health-related quality of life in patients with multiple sclerosis in Isfahan, Iran
Journal name European Journal of Neurology   Check publisher's open access policy
ISSN 1351-5101
1468-1331
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.1111/j.1468-1331.2011.03535.x
Volume 19
Issue 3
Start page 431
End page 437
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Background and purpose:  Quality of life (QoL) of patients with multiple sclerosis (MS) is worse than that of other chronic diseases. There is a need to examine the impact of fatigue and depression on the QoL independent of level of physical disability in MS. The aim of this study is to explore physical, psychological, and social aspects of health-related QoL (HRQoL) of MS patients in association with physical disability, fatigue, and depression.
Methods:  In a cross-sectional study, 281 (63.4% women, 36.6% men) patients with MS participated in the study. The HRQoL was assessed by the Persian version of the multiple sclerosis quality of life (MSQoL-54) questionnaires. Other covariates included in the study were disease type, physical disability, fatigue, disease impact, and depression.
Results:  In univariate analysis disease type, physical disability, fatigue, disease impact, and depression were significantly associated with both physical and mental health composite summaries of MSQoL-54. In multivariate regression analysis, patients’ physical disability remained significantly associated with both components of MSQoL-54, whilst fatigue and depression were associated with physical and mental composite summaries, respectively.
Conclusions:  Our findings suggest that MS-related physical disability, fatigue, and depression affect the HRQoL of MS patients, independently of each other and other potential confounding factors. Effective interventions that target fatigue and depression may help improve the QoL of patients, regardless of their disease type and level of disability.
Keyword Depression
Fatigue
Multiple sclerosis
Quality of life
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 4 OCT 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
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Created: Wed, 14 Mar 2012, 11:36:17 EST by Geraldine Fitzgerald on behalf of School of Public Health