Factors influencing risk of premature mortality in community cases of depression: A Meta-Analytic review

Baxter, Amanda J., Page, Andrew and Whiteford, Harvey A. (2012) Factors influencing risk of premature mortality in community cases of depression: A Meta-Analytic review. Epidemiology Research International, . doi:10.1155/2011/832945


Author Baxter, Amanda J.
Page, Andrew
Whiteford, Harvey A.
Total Author Count Override 3
Title Factors influencing risk of premature mortality in community cases of depression: A Meta-Analytic review
Journal name Epidemiology Research International   Check publisher's open access policy
ISSN 2090-2972
2090-2980
Publication date 2012
Year available 2011
Sub-type Article (original research)
DOI 10.1155/2011/832945
Open Access Status DOI
Total pages 12
Editor Susana Sans Menendez
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Collection year 2013
Language eng
Formatted abstract
Background.
Depressive disorders are associated with substantial risk of premature mortality. A number of factors may contribute to reported risk estimates, making it difficult to determine actual risk of excess mortality in community cases of depression. The aim of this study is to conduct a systematic review and meta-analysis of excess mortality in population-based studies of clinically defined depression.

Methods.
Population-based studies reporting all-cause mortality associated with a clinically defined depressive disorder were included in the systematic review. Estimates of relative risk for excess mortality in population-representative cases of clinical depressive disorders were extracted. A meta-analysis was conducted using Stata to pool estimates of excess mortality and identify sources of heterogeneity within the data.

Results.
Twenty-one studies reporting risk of excess mortality in clinical depression were identified. A significantly higher risk of mortality was found for major depression (RR 1.92 95% CI 1.65–2.23), but no significant difference was found for dysthymia (RR 1.37 95% CI 0.93–2.00). Relative risk of excess mortality was not significantly different following the adjustment of reported risk estimates.

Conclusion.
A mortality gradient was identified with increasing severity of clinical depression. Recognition of depressive symptoms in general practice and appropriate referral for evidence-based treatment may help improve outcomes, particularly in patients with comorbid physical disorders.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
 
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Created: Wed, 14 Mar 2012, 11:04:42 EST by Geraldine Fitzgerald on behalf of School of Public Health