Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis

Pereira, Tamara N., Walsh, Meagan J., Lewindon, Peter J. and Ramm, Grant A. (2010) Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis. World Journal of Gastrointestinal Pathophysiology, 1 2: 69-84. doi:10.4291/wjgp.v1.i2.69


Author Pereira, Tamara N.
Walsh, Meagan J.
Lewindon, Peter J.
Ramm, Grant A.
Title Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis
Journal name World Journal of Gastrointestinal Pathophysiology   Check publisher's open access policy
ISSN 2150-5330
Publication date 2010-06-15
Sub-type Article (original research)
DOI 10.4291/wjgp.v1.i2.69
Open Access Status DOI
Volume 1
Issue 2
Start page 69
End page 84
Total pages 16
Place of publication Beijing, China
Publisher Beijing Baishideng BioMed Scientific Co.
Language eng
Abstract Cholestatic liver disease causes significant morbidity and mortality in children. The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional therapy. There is no single gold standard test that accurately reflects the presence of liver disease, or that can be used to monitor fibrosis progression, particularly in conditions such as cystic fibrosis. This has lead to controversy over how suspected liver disease in children is detected and diagnosed. This review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver disease. In addition, the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention.
Keyword Cystic fibrosis
Biliary atresia
Liver biopsy
Ultrasound
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 14 Mar 2012, 20:53:34 EST by Melanie Thomas on behalf of Paediatrics & Child Health - RBWH