Hatching time for monotreme immunology

Wong, Emily S. W., Papenfuss, Anthony T., Miller, Robert D. and Belov, Katherine (2009) Hatching time for monotreme immunology. Australian Journal of Zoology, 57 3-4: 185-198. doi:10.1071/ZO09042

Author Wong, Emily S. W.
Papenfuss, Anthony T.
Miller, Robert D.
Belov, Katherine
Title Hatching time for monotreme immunology
Journal name Australian Journal of Zoology   Check publisher's open access policy
ISSN 0004-959X
Publication date 2009
Sub-type Article (original research)
DOI 10.1071/ZO09042
Open Access Status
Volume 57
Issue 3-4
Start page 185
End page 198
Total pages 15
Place of publication Collingwood, VIC, Australia
Publisher CSIRO Publishing
Language eng
Abstract The sequencing of the platypus genome has spurred investigations into the characterisation of the monotreme immune response. As the mostdivergentof extant mammals, the characterisation of the monotreme immune repertoire allows us to trace the evolutionary history of immunity in mammals and provide insights into the immune gene complement of ancestral mammals. The immune system of monotremes has remained largely uncharacterised due to the lack of specific immunological reagents and limited access to animals for experimentation. Early immunological studies focussed on the anatomy and physiology of the lymphoid system in the platypus. More recent molecular studies have focussed on characterisation of individual immunoglobulin, T-cell receptor and MHC genes in both the platypus and short-beaked echidna. Here, we review the published literature on the monotreme immune gene repertoire and provide new data generated from genome analysis on cytokines, Fc receptors and immunoglobulins. We present an overview of key gene families responsible for innate and adaptive immunity including the cathelicidins, defensins, T-cell receptors and the major histocompatibility complex (MHC) Class I and Class II antigens. We comment on the usefulness of these sequences for future studies into immunity, health and disease in monotremes.
Keyword Major Histocompatibility Complex
Short-beaked Echidna
Platypus Ornithorhynchus-anatinus
Duck Billed Platypus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 13 Mar 2012, 15:51:11 EST by Susan Allen on behalf of Institute for Molecular Bioscience