Genomic identification of chemokines and cytokines in Opossum

Wong, Emily S., Papenfuss, Anthony T. and Belov, Katherine (2011) Genomic identification of chemokines and cytokines in Opossum. Journal of Interferon and Cytokine Research, 31 3: 317-330. doi:10.1089/jir.2010.0045


Author Wong, Emily S.
Papenfuss, Anthony T.
Belov, Katherine
Title Genomic identification of chemokines and cytokines in Opossum
Journal name Journal of Interferon and Cytokine Research   Check publisher's open access policy
ISSN 1557-7465
1079-9907
Publication date 2011-02
Sub-type Article (original research)
DOI 10.1089/jir.2010.0045
Volume 31
Issue 3
Start page 317
End page 330
Total pages 14
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2012
Language eng
Formatted abstract
The cytokine repertoire of marsupials is largely unknown. The sequencing of the opossum genome has expedited the identification of many immune genes. However, many genes have not been identified using automated annotation pipelines because of high levels of sequence divergence. To fill gaps in our knowledge of the cytokine gene complement in marsupials, we searched the genome assembly of the gray short-tailed opossum for chemokine, interleukin, colony-stimulating factor, tumor necrosis factor, and transforming growth factor genes. In particular, we focused on genes that were not previously identified through Ensembl's automatic annotations. We report that the vast majority of cytokines are conserved, with direct orthologs between therian species. The major exceptions are chemokine genes, which show lineage-specific duplication/loss. Thirty-six chemokines were identified in opossum, including a lineage-specific expansion of macrophage inflammatory protein family genes. Divergent cytokines IL7, IL9, IL31, IL33, and CSF2 were identified. This is the first time IL31 and IL33 have been described outside of eutherian species. The high levels of similarities between the cytokine gene repertoires of therians suggest that the marsupial immune response is highly similar to eutherians.
Keyword Marsupial Monodelphis-domestica
Possum Trichosurus-vulpecula
Northern Brown bandicoot
Wallaby Macropus-eugeni
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 13 Mar 2012, 15:32:41 EST by Susan Allen on behalf of Institute for Molecular Bioscience