The association between mammographic density measures and aspirin or other NSAID use

Stone, Jennifer, Willenberg, Lisa, Apicella, Carmel, Treloar, Susan and Hopper, John (2012) The association between mammographic density measures and aspirin or other NSAID use. Breast Cancer Research and Treatment, 132 1: 259-266. doi:10.1007/s10549-011-1834-2


Author Stone, Jennifer
Willenberg, Lisa
Apicella, Carmel
Treloar, Susan
Hopper, John
Title The association between mammographic density measures and aspirin or other NSAID use
Journal name Breast Cancer Research and Treatment   Check publisher's open access policy
ISSN 0167-6806
1573-7217
Publication date 2012-02
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s10549-011-1834-2
Volume 132
Issue 1
Start page 259
End page 266
Total pages 8
Place of publication New York, United States
Publisher Springer
Collection year 2012
Language eng
Abstract There is evidence that aspirin use reduces the risk of breast cancer. Increased mammographic density is known to be associated with increased breast cancer risk. Little is known about the association between mammographic density and aspirin or other non-steroidal anti-inflammatory drug (NSAID) use, but it is possible that the association between aspirin use and breast cancer risk might be due to the effect of aspirin on mammographic density. Multiple linear regression was used to investigate the association between measures of mammographic density and the use, frequency, and duration of aspirin and other NSAIDs such as paracetamol (acetaminophen), arthritis medication, and other over-the-counter or doctor-prescribed pain medications in 3286 women from the Australian Mammographic Density Twins and Sisters Study and the Genes Behind Endometriosis Study. We found no association between either dense area or percent dense area with any of the NSAIDs examined (all P > 0.06). If aspirin is reducing the breast cancer risk in women, it is likely doing so via a different pathway other than mammographic density measures that predict breast cancer risk.
Keyword Mammographic density
Aspirin
NSAIDs
Breast cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 30 October 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Military and Veterans' Health Publications
 
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