Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients a pilot study

Ng, Arnold C. T., Auger, Dominique, Delgado, Victoria, van Elderen, Saskia G. C., Bertini, Matteo, Siebelink, Hans-Marc, van der Geest, Rob J., Bonetti, Cosimo, van der Velde, Enno T., de Roos, Albert, Smit, Johannes W.A., Leung, Dominic Y., Bax, Jeroen J. and Lamb, Hildo J. (2012) Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients a pilot study. Circulation: Cardiovascular Imaging, 5 1: 51-59. doi:10.1161/CIRCIMAGING.111.965608


Author Ng, Arnold C. T.
Auger, Dominique
Delgado, Victoria
van Elderen, Saskia G. C.
Bertini, Matteo
Siebelink, Hans-Marc
van der Geest, Rob J.
Bonetti, Cosimo
van der Velde, Enno T.
de Roos, Albert
Smit, Johannes W.A.
Leung, Dominic Y.
Bax, Jeroen J.
Lamb, Hildo J.
Title Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients a pilot study
Formatted title
Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients a pilot study
Journal name Circulation: Cardiovascular Imaging   Check publisher's open access policy
ISSN 1941-9651
1942-0080
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1161/CIRCIMAGING.111.965608
Volume 5
Issue 1
Start page 51
End page 59
Total pages 9
Place of publication Baltimore, MD, United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Formatted abstract
Background—Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T1 mapping is a previously validated imaging technique that can quantify the burden of global and regional interstitial fibrosis. However, the association between MRI T1 mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown.
Methods and Results—Fifty diabetic patients with normal LV ejection fraction (EF) and no underlying coronary artery disease or regional macroscopic scar on MRI delayed enhancement were prospectively recruited. Diabetic patients were compared with 19 healthy controls who were frequency matched in age, sex and body mass index. There were no significant differences in mean LV end-diastolic volume index, end-systolic volume index and LVEF between diabetic patients and healthy controls. Diabetic patients had significantly shorter global contrast-enhanced myocardial T1 time (425±72 ms vs. 504±34 ms, P<0.001). There was no correlation between global contrast-enhanced myocardial T1 time and LVEF (r=0.14, P=0.32) in the diabetic patients. However, there was good correlation between global contrast-enhanced myocardial T1 time and global longitudinal strain (r=−0.73, P<0.001). Global contrast-enhanced myocardial T1 time was the strongest independent determinant of global longitudinal strain on multivariate analysis (standardized β=−0.626, P<0.001). Similarly, there was good correlation between global contrast-enhanced myocardial T1 time and septal E′ (r=0.54, P<0.001). Global contrast-enhanced myocardial T1 time was also the strongest independent determinant of septal E′ (standardized β=0.432, P<0.001).
Conclusions—A shorter global contrast-enhanced myocardial T1 time was associated with more impaired longitudinal myocardial systolic and diastolic function in diabetic patients.
Keyword Diabetes mellitus
Echocardiography
MRI
Left ventricular fibrosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print December 1, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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