Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes

Mestankova, Hana, Schirmer, Kristin, Escher, Beate I., von Gunten, Urs and Canonica, Silvio (2012) Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes. Environmental Pollution, 161 30-35. doi:10.1016/j.envpol.2011.09.018


Author Mestankova, Hana
Schirmer, Kristin
Escher, Beate I.
von Gunten, Urs
Canonica, Silvio
Title Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes
Journal name Environmental Pollution   Check publisher's open access policy
ISSN 0269-7491
1873-6424
Publication date 2012-02
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.envpol.2011.09.018
Volume 161
Start page 30
End page 35
Total pages 6
Collection year 2013
Language eng
Formatted abstract
The antiviral agent oseltamivir acid (OA, the active metabolite of Tamiflu®) may occur at high concentrations in wastewater during pandemic influenza events. To eliminate OA and its antiviral activity from wastewater, ozonation and advanced oxidation processes were investigated. For circumneutral pH, kinetic measurements yielded second-order rate constants of 1.7 ± 0.1 × 105 and 4.7 ± 0.2 × 109 M−1 s−1 for the reaction of OA with ozone and hydroxyl radical, respectively. During the degradation of OA by both oxidants, the antiviral activity of the treated aqueous solutions was measured by inhibition of neuraminidase activity of two different viral strains. A transient, moderate (two-fold) increase in antiviral activity was observed in solutions treated up to a level of 50% OA transformation, while for higher degrees of transformation the activity corresponded to that caused exclusively by OA. OA was efficiently removed by ozonation in a wastewater treatment plant effluent, suggesting that ozonation can be applied to remove OA from wastewater.
Keyword Tamiflu
Ozone
Hydroxyl radical
Degradation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 23 October 2011. Special issue: Mercury in the Laurentian Great Lakes Region.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
National Research Centre for Environmental Toxicology Publications
 
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