A novel impinging aerosols method for production of propranolol hydrochloride-loaded alginate gel microspheres for oral delivery

Hariyadi, Dewi Melani, Bostrom, Thor, Bhandari, Bhesh and Coombes, Allan G. A. (2012) A novel impinging aerosols method for production of propranolol hydrochloride-loaded alginate gel microspheres for oral delivery. Journal of Microencapsulation, 29 1: 63-71.


Author Hariyadi, Dewi Melani
Bostrom, Thor
Bhandari, Bhesh
Coombes, Allan G. A.
Title A novel impinging aerosols method for production of propranolol hydrochloride-loaded alginate gel microspheres for oral delivery
Journal name Journal of Microencapsulation  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2012
Sub-type Article
DOI 10.3109/02652048.2011.629746
Volume number 29
Issue number 1
ISSN 0265-2048; 1464-5246
Start page 63
End page 71
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2013
Language eng
Formatted abstract Propranolol hydrochloride was directly encapsulated in alginate gel microspheres (40–50 µm in diameter) using a novel method involving impinging aerosols of CaCl2 cross-linking solution and sodium alginate solution containing the drug. Microspheres formulated using 0.1 M CaCl2 exhibited the highest drug loading (14%, w/w of dry microspheres) with 66.5% encapsulation efficiency. Less than 4% and 35% propranolol release occurred from hydrated and dried microspheres, respectively, in 2 h in simulated gastric fluid (SGF). The majority of the drug load (90%) was released in 5 and 7 h from hydrated and dried microspheres, respectively, in simulated intestinal fluid (SIF). Prior incubation of hydrated microspheres (cross-linked using 0.5 M CaCl2) in SGF prolonged the time of release in SIF to 10 h, which has implications for the design of protocols and correlation with in vivo release behaviour. Restricted propranolol release in SGF and complete extraction in SIF demonstrate the potential of alginate gel microspheres for oral delivery of pharmaceuticals.
Keyword Alginate gel microspheres
Impinging aerosols
Propranolol hydrochloride
ESEM
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article
Collections: School of Agriculture and Food Sciences
Official 2013 Collection
School of Pharmacy Publications
 
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