Slc13a1 and Slc26a1 Ko models reveal physiological roles of anion transporters

Markovich, Daniel (2012) Slc13a1 and Slc26a1 Ko models reveal physiological roles of anion transporters. Physiology, 27 1: 7-14. doi:10.1152/physiol.00041.2011


Author Markovich, Daniel
Total Author Count Override 1
Title Slc13a1 and Slc26a1 Ko models reveal physiological roles of anion transporters
Journal name Physiology   Check publisher's open access policy
ISSN 1548-9213
1548-9221
Publication date 2012-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/physiol.00041.2011
Volume 27
Issue 1
Start page 7
End page 14
Total pages 8
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2013
Language eng
Abstract Anion transporters NaS1 (SLC13A1) and Sat1 (SLC26A1) mediate sulfate (re)absorption across renal proximal tubule and small intestinal epithelia, thereby regulating blood sulfate levels. Disruption of murine NaS1 and Sat1 genes leads to hyposulfatemia and hypersulfaturia. Sat1-null mice also exhibit hyperoxalemia, hyperoxaluria, and calcium oxalate urolithiasis. This review will highlight the current pathophysiological features of NaS1- and Sat1-null mice resulting from alterations in circulating sulfate and oxalate anion levels.
Keyword Contraluminal sulfate Transport
Basolateral membrane-vesicles
Cotransporter gene Nas1
Proximal renal tubule
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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