Flavivirus replication and assembly

Roby, Justin A., Funk, Anneke and Khromykh, Alexander A. (2012). Flavivirus replication and assembly. In Pei-Yong Shi (Ed.), Molecular virology and control of flaviviruses (pp. 21-49) Norfolk, United Kingdom: Caister Academic Press.

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Name Description MIMEType Size Downloads
Author Roby, Justin A.
Funk, Anneke
Khromykh, Alexander A.
Title of chapter Flavivirus replication and assembly
Title of book Molecular virology and control of flaviviruses
Place of Publication Norfolk, United Kingdom
Publisher Caister Academic Press
Publication Year 2012
Sub-type Research book chapter (original research)
ISBN 9781904455929
Editor Pei-Yong Shi
Chapter number 3
Start page 21
End page 49
Total pages 29
Total chapters 15
Collection year 2013
Language eng
Formatted Abstract/Summary
The replication and assembly of Flaviviruses are complex procedures, which require the efficient coordination of a number of different steps. These stages are highly organized temporally and spatially in the infected cell and require the virus-induced establishment of host-derived membrane structures. Flavivirus RNA structures, non-structural proteins and host factors actively participate in the replication of genomic RNA within vesicle packets (VP). Progeny (+) strand RNA exits the VP pore and is incorporated into nucleocapsids by the capsid protein. Nucleocapsids are then presumably transported into the lumen of the endoplasmic reticulum at sites directly opposed to the VP pore during formation of the prM-E studded lipid envelope. These immature virions are trafficked to the Golgi network in individual vesicles for glycoprotein maturation and furin-directed prM cleavage. Mature virions (with associated, cleaved prM) are then secreted into the extracellular milieu.
Keyword West-nile-virus
Dependent Rna-polymerase
Nonstructural protein Ns1
N-linked glycosylation
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 09 Mar 2012, 09:03:45 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences