Sulfurous gases as biological messengers and toxins: Comparative genetics of their metabolism in model organisms

Mathew, Neal D., Schlipalius, David I. and Ebert, Paul R. (2011) Sulfurous gases as biological messengers and toxins: Comparative genetics of their metabolism in model organisms. Journal of Toxicology, 2011 394970.1-394970.14. doi:10.1155/2011/394970

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Author Mathew, Neal D.
Schlipalius, David I.
Ebert, Paul R.
Title Sulfurous gases as biological messengers and toxins: Comparative genetics of their metabolism in model organisms
Journal name Journal of Toxicology   Check publisher's open access policy
ISSN 1687-8191
1687-8205
Publication date 2011
Sub-type Article (original research)
DOI 10.1155/2011/394970
Open Access Status DOI
Volume 2011
Start page 394970.1
End page 394970.14
Total pages 14
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Collection year 2012
Language eng
Formatted abstract
Gasotransmitters are biologically produced gaseous signalling molecules. As gases with potent biological activities, they are toxic as air pollutants, and the sulfurouscompounds are used as fumigants.Most investigations focus on medical aspects of gasotransmitter biology rather than toxicity toward invertebrate pests of agriculture. In fact, the pathways for the metabolism of sulfur containing gases in lower organisms have not yet been described. To address this deficit, we use protein sequences from Homo sapiens to query Genbank for homologous proteins in Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae. In C. elegans, we find genes for all mammalian pathways for synthesis and catabolism of the three sulfur containing gasotransmitters, H2S, SO2 and COS. The genes for H2S synthesis have actually increased in number in C. elegans. Interestingly, D. melanogaster and Arthropoda in general, lack a gene for 3-mercaptopyruvate sulfurtransferase, an enzym for H2S synthesis under reducing conditions.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 394970

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
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Created: Thu, 08 Mar 2012, 15:20:06 EST by Gail Walter on behalf of School of Biological Sciences