Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organisation

Hui, Jerome H.L., McDougal, Carmell, Monteiro, Ana S., Holland, Peter W. H., Arendt, Detlev, Balavoine, Guillaume and Ferrier, David E. K. (2011) Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organisation. Molecular Biology and Evolution, 29 1: 157-165. doi:10.1093/molbev/msr175


Author Hui, Jerome H.L.
McDougal, Carmell
Monteiro, Ana S.
Holland, Peter W. H.
Arendt, Detlev
Balavoine, Guillaume
Ferrier, David E. K.
Title Extensive chordate and annelid macrosynteny reveals ancestral homeobox gene organisation
Language of Title eng
Journal name Molecular Biology and Evolution   Check publisher's open access policy
Language of Journal Name eng
ISSN 0737-4038
1537-1719
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1093/molbev/msr175
Volume 29
Issue 1
Start page 157
End page 165
Total pages 9
Place of publication Cary, NC, United States
Publisher Oxford University Pres
Collection year 2012
Language eng
Abstract Genes with the homeobox motif are crucial in developmental biology and widely implicated in the evolution of development. The Antennapedia (ANTP)-class is one of the two major classes of animal homeobox genes, and includes the Hox genes, renowned for their role in patterning the anterior–posterior axis of animals. The origin and evolution of the ANTP-class genes are a matter of some debate. A principal guiding hypothesis has been the existence of an ancient gene Mega-cluster deep in animal ancestry. This hypothesis was largely established from linkage data from chordates, and the Mega-cluster hypothesis remains to be seriously tested in protostomes. We have thus mapped ANTP-class homeobox genes to the chromosome level in a lophotrochozoan protostome. Our comparison of gene organization in Platynereis dumerilii and chordates indicates that the Mega-cluster, if it did exist, had already been broken up onto four chromosomes by the time of the protostome–deuterostome ancestor (PDA). These results not only elucidate an aspect of the genome organization of the PDA but also reveal high levels of macrosynteny between P. dumerilii and chordates. This implies a very low rate of interchromosomal genome rearrangement in the lineages leading to P. dumerilii and the chordate ancestor since the time of the PDA.
Keyword Platynereis dumerilii
Antennapedia-class
Homeobox
Protostome–deuterostome ancestor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
 
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Created: Thu, 08 Mar 2012, 14:44:53 EST by Gail Walter on behalf of School of Biological Sciences