Genetic polymorphism studies in periodontitis and Fcγ receptors

Chai,L., Song,Y. -Q. and Leung.W. K. (2012) Genetic polymorphism studies in periodontitis and Fcγ receptors. Journal of Periodontal Research, 47 3: 273-285. doi:10.1111/j.1600-0765.2011.01437.x

Author Chai,L.
Song,Y. -Q.
Leung.W. K.
Title Genetic polymorphism studies in periodontitis and Fcγ receptors
Journal name Journal of Periodontal Research   Check publisher's open access policy
ISSN 0022-3484
Publication date 2012-06
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-0765.2011.01437.x
Volume 47
Issue 3
Start page 273
End page 285
Total pages 13
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Collection year 2013
Language eng
Abstract Periodontitis is a complex chronic subgingival plaque-induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fcγ receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fcγ receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fcγ receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fcγ receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.
Keyword Fcγ receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 27 NOV 2011

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 07 Mar 2012, 14:20:19 EST by Dr Lei Chai on behalf of School of Dentistry