Tissue organization by cadherin adhesion molecules: Dynamic molecular and cellular mechanisms of morphogenetic regulation

Niessen, Carien M., Leckband, Deborah and Yap, Alpha S. (2011) Tissue organization by cadherin adhesion molecules: Dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiological Reviews, 91 2: 691-731. doi:10.1152/physrev.00004.2010


Author Niessen, Carien M.
Leckband, Deborah
Yap, Alpha S.
Title Tissue organization by cadherin adhesion molecules: Dynamic molecular and cellular mechanisms of morphogenetic regulation
Language of Title eng
Journal name Physiological Reviews   Check publisher's open access policy
Language of Journal Name eng
ISSN 0031-9333
1522-1210
Publication date 2011-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/physrev.00004.2010
Volume 91
Issue 2
Start page 691
End page 731
Total pages 41
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Collection year 2012
Language eng
Formatted abstract
This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations of cells in organs and tissues. In metazoa, adhesion receptors of the classical cadherin family play important roles in establishing and maintaining such tissue organization. Indeed, it is apparent that cadherins participate in a range of morphogenetic events that range from support of tissue integrity to dynamic cellular rearrangements. A comprehensive understanding of cadherin-based morphogenesis must then define the molecular and cellular mechanisms that support these distinct cadherin biologies. Here we focus on four key mechanistic elements: the molecular basis for adhesion through cadherin ectodomains, the regulation of cadherin expression at the cell surface, cooperation between cadherins and the actin cytoskeleton, and regulation by cell signaling. We discuss current progress and outline issues for further research in these fields.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 134 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 143 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 07 Mar 2012, 14:12:46 EST by Susan Allen on behalf of Institute for Molecular Bioscience