A study of retinal penetration of intravitreal tenecteplase in pigs

Kwan, Anthony S. L., Vijayasekaran, Sarojini, McAllister, Ian L., Yu, Paula K. and Yu, Dao-Yi (2006) A study of retinal penetration of intravitreal tenecteplase in pigs. Investigative Ophthalmology and Visual Science, 47 6: 2662-2667. doi:10.1167/iovs.05-1019

Author Kwan, Anthony S. L.
Vijayasekaran, Sarojini
McAllister, Ian L.
Yu, Paula K.
Yu, Dao-Yi
Title A study of retinal penetration of intravitreal tenecteplase in pigs
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 0146-0404
Publication date 2006-06
Sub-type Article (original research)
DOI 10.1167/iovs.05-1019
Volume 47
Issue 6
Start page 2662
End page 2667
Total pages 6
Place of publication Rockville, MD, United States
Publisher Association for Research in Vision and Ophthalmology
Language eng
Formatted abstract
PURPOSE. To determine the degree of retinal penetration of intravitreal tenecteplase in a porcine model.
METHODS. Fluorescence-tagged tenecteplase (50 μg in 0.1 mL physiologic saline) was injected into the vitreous of the right and left eyes at 24 and 6 hours before death, respectively, in six nonvitrectomized pigs. Retinal penetration was assessed on frozen sections by epifluorescence microscopy and statistical analysis was performed. Frozen sections of two eyes without injection (control) were also assessed.
RESULTS. Labeling of fluorescence-tagged tenecteplase was seen in all the layers of the retina at both time points with more intense signal at 24 hours after injection (P < 0.05).
CONCLUSIONS. Fluorescence-tagged tenecteplase can penetrate all the layers of the retina of porcine eyes after intravitreal injection. Intravitreal tenecteplase may be useful in the in the management of subretinal hemorrhage.
Keyword Tissue plasminogen activator
Acute myocardial infarction
Macular subretinal hemorrhage
Single-bolus tenecteplase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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