Effect of high shear wet milling (HSWM) of recrystallized ibuprofen particles on its flow properties for solid dosage pharmaceutical formulation

Rashid, Abdur, Marziano, Ivan, White, Ted, Howes, Tony, Litster, Jim and Liu, Lian X. (2011). Effect of high shear wet milling (HSWM) of recrystallized ibuprofen particles on its flow properties for solid dosage pharmaceutical formulation. In: Chemeca 2011 Proceedings. Chemeca 2011: Australasian Conference on Chemical Engineering, Sydney, Australia, (1-10). 18-21 September 2011.

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Author Rashid, Abdur
Marziano, Ivan
White, Ted
Howes, Tony
Litster, Jim
Liu, Lian X.
Title of paper Effect of high shear wet milling (HSWM) of recrystallized ibuprofen particles on its flow properties for solid dosage pharmaceutical formulation
Conference name Chemeca 2011: Australasian Conference on Chemical Engineering
Conference location Sydney, Australia
Conference dates 18-21 September 2011
Proceedings title Chemeca 2011 Proceedings
Place of Publication Barton, ACT, Australia
Publisher Engineers Australia
Publication Year 2011
Sub-type Fully published paper
ISBN 9780858259225
Start page 1
End page 10
Total pages 10
Collection year 2012
Language eng
Abstract/Summary To design advanced pharmaceutical formulations it is essential to control the particle size of the active drug ingredients. This study investigates the particle size reduction by HSWM, (Silverson® mill) of recrystallized ibuprofen particles and how these particles influence its properties during process formulation. The procedures used are as follows: (1) preparing an ibuprofen solution in 30% water – ethanol mixture at 40 °C; (2) recrystallizing it by cooling the solution to 0 °C; (3) reducing the crystal size by in-situ Process Analytical Techniques (PAT) (Labmax® coupled with HSWM) with the particle size measured by a Lasentec Focused Beam Reflectance Measurement, FBRM®. Subsequently the flow properties of the milled ibuprofen particles and its binary mixtures with lactose were measured using a Schulze® RST-XS ring shear tester. Results show that the morphology of ibuprofen was changed from needle to hexagonal like crystals during recrystallization and crystal size was reduced dramatically by the HSWM for 1 hour. The flowability of milled ibuprofen powders is reduced significantly due to its reduced size and change of surface morphology. Mixing the HSWM ibuprofen powders with lactose enhanced its flow properties. However, the increase of the mixture flowability is less significant in comparison to the binary mixtures of lactose with ibuprofen without HSWM.
Q-Index Code E1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Paper number 423

Document type: Conference Paper
Collections: School of Chemical Engineering Publications
Official 2012 Collection
 
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Created: Tue, 06 Mar 2012, 15:39:27 EST by Professor Edward White on behalf of School of Chemical Engineering