Effect of molecular architecture on the performance of (19)F NMR imaging agents

Peng, Hui, Thurecht, Kristofer, Hsu, Steven, Blakey, Idriss, Squires, Oliver, Kurniawan, Nyoman, Rose, Stephen and Whittaker, Andrew (2011). Effect of molecular architecture on the performance of (19)F NMR imaging agents. In H. N. Cheng, Tetsuo Asakur and Alan D. English (Ed.), NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules (pp. 459-472) Washington, DC, United States: American Chemical Society. doi:10.1021/bk-2011-1077.ch028


Author Peng, Hui
Thurecht, Kristofer
Hsu, Steven
Blakey, Idriss
Squires, Oliver
Kurniawan, Nyoman
Rose, Stephen
Whittaker, Andrew
Title of chapter Effect of molecular architecture on the performance of (19)F NMR imaging agents
Formatted title
Effect of molecular architecture on the performance of 19F NMR imaging agents
Title of book NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules
Place of Publication Washington, DC, United States
Publisher American Chemical Society
Publication Year 2011
Sub-type Research book chapter (original research)
DOI 10.1021/bk-2011-1077.ch028
Open Access Status
Series ACS Symposium Series
ISBN 9780841226678
0841226679
9780841226685
0841226687
ISSN 0097-6156
1947-5918
Editor H. N. Cheng
Tetsuo Asakur
Alan D. English
Volume number 1077
Chapter number 28
Start page 459
End page 472
Total pages 14
Total chapters 32
Collection year 2012
Language eng
Formatted Abstract/Summary
Traditional magnetic resonance medical imaging agents based on paramagnetic ions or particles have a number of critical limitations, namely image contrast is often limited at low concentrations and sensitivity of the agents becomes diminished at higher magnetic field strengths. In this chapter we describe the development of a new class of polymeric imaging agent which relies on direct detection of the NMR signal of fluorine nuclei and hence circumvents these potential problems. The imaging performance of the new materials relies on the maintenance of librational motion of the fluorinated segments, necessary for partial averaging of the otherwise strong dipole-dipole interactions and large chemical shift interactions of the 19F nuclei. The performance of partially-fluorinated block copolymers assembled into particles is described and related to the interactions of the polymer chains with the surrounding solvent medium. A second generation of materials based on a hyperbranched structure was developed based on the learning obtained from the earlier experiments and these demonstrated excellent in vitro and in vivo imaging performance.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: "NMR Spectroscopy of Polymers: Innovative Strategies for Complex Macromolecules": selected papers from a symposium held at the Pacifichem meeting on December 17-21, 2010 in Honolulu, Hawaii.

 
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Created: Tue, 06 Mar 2012, 15:19:21 EST by Dr Kristofer Thurecht on behalf of Aust Institute for Bioengineering & Nanotechnology