Familial hypercholesterolaemia: A model of care for Australasia

Watts, Gerald F., Sullivan, David R., Poplawski, Nicola, van Bockxmeer, Frank, Hamilton-Craig, Ian, Clifton, Peter M., O'Brien, Richard, Bishop, Warrick, George, Peter, Barter, Phillip J., Bates, Timothy, Burnett, John R., Coakley, John, Davidson, Pattricia, Emery, Jon, Martin, Andrew, Farid, Waleed, Freeman, Lucinda, Geelhoed, Elizabeth, Juniper, Amanda, Kidd, Alexa, Kostner, Kakam, Krass, Ines, Livingston, Michael, Maxwell, Suzy, O'Leary, Peter, Owaimrin, Amal, Redgrave, Trevor G., Reid, Nicola, Southwell, Lynda, Suthers, Graeme, Tonkin, Andrew, Towler, Simon, Trent, Ronald, Familial Hypercholesterolaemia and Australian Atherosclerosis Soc (2011) Familial hypercholesterolaemia: A model of care for Australasia. Atherosclerosis Supplements, 12 2: 221-263. doi:10.1016/j.atherosclerosissup.2011.06.001

Author Watts, Gerald F.
Sullivan, David R.
Poplawski, Nicola
van Bockxmeer, Frank
Hamilton-Craig, Ian
Clifton, Peter M.
O'Brien, Richard
Bishop, Warrick
George, Peter
Barter, Phillip J.
Bates, Timothy
Burnett, John R.
Coakley, John
Davidson, Pattricia
Emery, Jon
Martin, Andrew
Farid, Waleed
Freeman, Lucinda
Geelhoed, Elizabeth
Juniper, Amanda
Kidd, Alexa
Kostner, Kakam
Krass, Ines
Livingston, Michael
Maxwell, Suzy
O'Leary, Peter
Owaimrin, Amal
Redgrave, Trevor G.
Reid, Nicola
Southwell, Lynda
Suthers, Graeme
Tonkin, Andrew
Towler, Simon
Trent, Ronald
Familial Hypercholesterolaemia
Australian Atherosclerosis Soc
Title Familial hypercholesterolaemia: A model of care for Australasia
Journal name Atherosclerosis Supplements   Check publisher's open access policy
ISSN 1567-5688
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosissup.2011.06.001
Volume 12
Issue 2
Start page 221
End page 263
Total pages 43
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that causes marked elevation in plasma cholesterol and premature coronary heart disease. There are at least 45,000 people with FH in Australia and New Zealand, but the vast majority remains undetected and those diagnosed with the condition are inadequately treated.

To bridge this major gap in coronary prevention the FH Australasia Network (Australian Atherosclerosis Society) has developed a consensus model of care (MoC) for FH. The MoC is based on clinical experience, expert opinion, published evidence and consultations with a wide spectrum of stakeholders, and has been developed for use primarily by specialist centres intending starting a clinical service for FH. This MoC aims to provide a standardised, high-quality and cost-effective system of care that is likely to have the highest impact on patient outcomes.

The MoC for FH is presented as a series of recommendations and algorithms focusing on the standards required for the detection, diagnosis, assessment and management of FH in adults and children. The process involved in cascade screening and risk notification, the backbone for detecting new cases of FH, is detailed. Guidance on treatment is based on risk stratifying patients, management of non-cholesterol risk factors, safe and effective use of statins, and a rational approach to follow-up of patients. Clinical and laboratory recommendations are given for genetic testing. An integrative system for providing best clinical care is described.

This MoC for FH is not prescriptive and needs to be complemented by good clinical judgment and adjusted for local needs and resources. After initial implementation, the MoC will require critical evaluation, development and appropriate modification.
Keyword Familial hypercholesterolaemia
Model of Care
Genetic testing
Cascade screening
Association Expert Panel
Coronary heart disease
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 60 times in Thomson Reuters Web of Science Article | Citations
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