Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample

McLean, Duncan, Gladman, Beverley and Mowry, Bryan (2012) Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample. Australian and New Zealand Journal of Psychiatry, 46 2: 132-140. doi:10.1177/0004867411433211


Author McLean, Duncan
Gladman, Beverley
Mowry, Bryan
Title Significant relationship between lifetime alcohol use disorders and suicide attempts in an Australian schizophrenia sample
Journal name Australian and New Zealand Journal of Psychiatry   Check publisher's open access policy
ISSN 0004-8674
1440-1614
Publication date 2012-02-01
Sub-type Article (original research)
DOI 10.1177/0004867411433211
Volume 46
Issue 2
Start page 132
End page 140
Total pages 9
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2013
Language eng
Formatted abstract
Objective:
Suicide and attempted suicide are common in individuals with schizophrenia, and evidence exists for a link between substance use disorders and suicidality in this disorder. However, alcohol has not been consistently implicated. We examined the relationship between substance use disorders and suicide attempts in schizophrenia.

Methods:

We recruited a schizophrenia sample in Australia (n = 821) for genetic analyses. We analysed demographic and clinical variables, including substance use disorders, and their relationship to suicide attempts using generalised equation modelling.

Results:

A significant association was identified between lifetime alcohol abuse/dependence and suicide attempts (OR = 1.66; 95% CI, 1.23 to 2.24; p= 0.001) after adjustment for potential confounders, but not between cannabis abuse/dependence and suicide attempts, nor between other illicit drug abuse/dependence and suicide attempts. Polysubstance abuse/dependence was also not implicated.

Conclusions:
These results suggest that the presence of alcohol abuse/dependence may be a risk factor for suicide attempts in individuals with schizophrenia, independent of comorbid substance abuse/dependence.
Keyword Suicide
Attempted suicide
Schizophrenia
Alcoholism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2013 Collection
 
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