Health symptoms during midlife in relation to menopausal transition: British prospective cohort study

Mishra, Gita D. and Kuh, Diana (2012) Health symptoms during midlife in relation to menopausal transition: British prospective cohort study. British Medical Journal, 344 7846: e402.1-e402.10. doi:10.1136/bmj.e402

Author Mishra, Gita D.
Kuh, Diana
Title Health symptoms during midlife in relation to menopausal transition: British prospective cohort study
Journal name British Medical Journal
ISSN 0959-535X
Publication date 2012-02
Sub-type Article (original research)
DOI 10.1136/bmj.e402
Volume 344
Issue 7846
Start page e402.1
End page e402.10
Total pages 10
Place of publication London, United Kingdom
Publisher BMJ Group
Collection year 2013
Language eng
Formatted abstract
Objective To characterise symptoms experienced by women during the transition into natural menopause, to classify women into distinct symptom profiles or trajectories, and to relate these profiles to sociodemographic factors and health behaviours.

Nationally representative cohort study.

England, Scotland, and Wales. Participants 695 women followed-up since birth in 1946 and annually from age 47 to 54 who experienced natural menopause and reported on 20 common health symptoms.

Main outcome measure
Longitudinal profiles for reported bothersome symptoms.

Of 20 individual symptoms, 18 formed into four stable symptom groups: psychological, somatic, vasomotor, and sexual discomfort. Using latent class  analyses, all except the somatic group of symptoms showed a clear relation with the timing of menopause for some women. A small proportion of women (10%, n=63) had a severe psychological symptom profile that peaked at or in the year after menopause. For vasomotor symptoms, 14% of women (n=83) had the early severe profile that also peaked around early postmenopause and then declined noticeably; 11% (n=67) had the late severe profile of bothersome symptoms that increased rapidly in perimenopause and remained high for four years or more after menopause. Women were less likely to have a profile for severe vasomotor symptoms if they were from a non-manual social class (odds ratio 0.79, 95% confidence interval 0.57 to 1.01) or had degree level qualifications (0.37, 0.18 to 0.77). The 14% of women (n=85) who had the late severe profile for sexual discomfort showed a similar increase in symptoms until menopause, with symptoms persisting after menopause. Married women were more likely to have the late severe or late moderate profile than women of other marital status (2.40, 1.30 to 4.41). Four profiles each were identified for somatic symptoms (mild, moderate, severe, and very severe), although these did not vary by chronological age or age at menopause.

Profiles for psychological, vasomotor, and sexual discomfort symptoms relative to age at menopause could help health professionals to tailor their advice for women with natural menopause.
Keyword Latent Class Analysis
Womens Health
Vasomotor Symptoms
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Public Health Publications
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