A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies

Zee, Yoke Leng Michelle, Gahan, Lawrence R. and Schenk, Gerhard (2011) A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies. Australian Journal of Chemistry, 64 3: 258-264.


Author Zee, Yoke Leng Michelle
Gahan, Lawrence R.
Schenk, Gerhard
Title A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies
Formatted title A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies
Language of Title eng
Journal name Australian Journal of Chemistry   Check publisher's open access policy
Language of Journal Name eng
ISSN 0004-9425
1445-0038
Publication date 2011-03-11
Year available 2011
Sub-type Article (original research)
DOI 10.1071/CH10424
Volume 64
Issue 3
Start page 258
End page 264
Total pages 7
Editor Wentrup, Curt
Place of publication Collingwood, VIC, Australia
Publisher CSIRO Publishing
Collection year 2012
Language eng
Formatted abstract An analogue of the purple acid phosphatase biomimetic 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((2-hydroxybenzyl)(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol has been synthesized. The analogue, 2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-(((2-hydroxy-4-(4-vinylbenzyloxy)benzyl)(pyridin-2-ylmethyl)amino)methyl)-4-methylphenol (H2BPBPMPV) possesses a pendant olefin suitable for copolymerization. Complexation with FeIII/ZnII resulted in the complex [FeIIIZnII(BPBPMPV)(CH3COO)2](ClO4), characterized with mass spectrometry, microanalysis, UV/vis, and IR spectrometry. The catalytic activity of the complex toward bis-(2,4-dinitrophenyl) phosphate was determined, resulting in Km of 4.1 ± 0.6 mM, with kcat 3.8 ± 0.2 × 10–3 s–1 and a bell-shaped pH–rate profile with pKa values of 4.31, 5.66, 8.96, the profile exhibiting residual activity above pH 9.5.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Thu, 01 Mar 2012, 13:35:35 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences