Alteration of Alveolar Macrophage Functions After Aerosol Infection with Bovine Herpesvirus Type-1

Ohmann, H. Bielefeldt and Babiuk, L. A. (1986) Alteration of Alveolar Macrophage Functions After Aerosol Infection with Bovine Herpesvirus Type-1. Infection and Immunity, 51 1: 344-347.

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Author Ohmann, H. Bielefeldt
Babiuk, L. A.
Title Alteration of Alveolar Macrophage Functions After Aerosol Infection with Bovine Herpesvirus Type-1
Journal name Infection and Immunity
ISSN 1098-5522
1070-6313
Publication date 1986-01
Sub-type Other
Open Access Status File (Publisher version)
Volume 51
Issue 1
Start page 344
End page 347
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Calves were aerosol challenged with bovine herpesvirus type I, and bronchoalveolar cells were subsequently retrieved by lavage from days 1 to 8 postinfection. Alveolar macrophages (AM), which were depleted of contaminating cells, were characterized with respect to phenotypic markers and functional activities. In most aspects, the changes suggested a stimulation of the AM. With variations in kinetics the percentage of AM expressing an MHC II antigen and Fc (immunoglobulin G)-mediated phagocytosis increased, as did the activity level of two ectoenzymes and the lysosomal hydrolase beta-glucoronidase. The generation of prostaglandin E2 by the AM also rose significantly. However, selective suppression of cellular cytotoxicity and interleukin-1 generation was observed. These findings may have important implications for understanding the events involved in the virus-bacterial interaction in respiratory diseases.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Other
Collections: School of Chemistry and Molecular Biosciences
School of Veterinary Science Publications
 
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