Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta)

Bielefeldt-Ohmann, H., Barouch, D.H., Bakke, A.M., Bruce, A.G., Durning, M., Grant, R., Letvin, N.L., Ryan, J.T., Schmidt, A., Thouless, M.E. and Rose, T.M. (2005) Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta). Veterinary Pathology, 42 3: 391-396. doi:10.1354/vp.42-3-391


Author Bielefeldt-Ohmann, H.
Barouch, D.H.
Bakke, A.M.
Bruce, A.G.
Durning, M.
Grant, R.
Letvin, N.L.
Ryan, J.T.
Schmidt, A.
Thouless, M.E.
Rose, T.M.
Title Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta)
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
1544-2217
Publication date 2005-05
Sub-type Article (original research)
DOI 10.1354/vp.42-3-391
Open Access Status Not Open Access
Volume 42
Issue 3
Start page 391
End page 396
Total pages 6
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Formatted abstract
Multifocal submucosal stromal tumors were diagnosed in a 5.5-year-old rhesus macaque (Macaca mulatta) experimentally infected with simian immunodeficiency virus, strain SIVsmE660, and CD4+ T cell depleted. The animal was negative for simian retroviruses, SRV-1, -2, and -5. Polymerase chain reaction analysis of DNA from tumor and spleen tissue revealed abundant, preferential presence of retroperitoneal fibromatosis herpesvirus, the macaque homologue of the Kaposi sarcoma-associated herpesvirus (human herpesvirus-8), in the tumors. This was corroborated by demonstration of viral latent nuclear antigen-1 in the nuclei of a majority of the spindeloid tumor cells. Low levels of an additional macaque herpesvirus, rhesus rhadinovirus, were also detected in the spleen and tumor tissues. The spindeloid cells labeled positively for vimentin and CD117 but were negative for CD31, CD68, desmin, and smooth muscle cell actin. Collectively, these findings suggest a relation to but not absolute identity with simian mesenchymoproliferative disorders (MPD) or typical gastrointestinal stromal tumors (GISTs).
Keyword Colon
Intestinal strornal tumors
Macaca mulatta
Mesenchymoproliferative disorders
Rhadinovirus
Simian immunodeficiency virus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Veterinary Science Publications
 
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