Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic

Griffiths, Amanda L., Wurzel, Danielle F., Robinson, Phil J., Carzino, Rosemary and Massie, John (2012) Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic. Journal of Cystic Fibrosis, 11 1: 49-52. doi:10.1016/j.jcf.2011.08.005


Author Griffiths, Amanda L.
Wurzel, Danielle F.
Robinson, Phil J.
Carzino, Rosemary
Massie, John
Title Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
ISSN 1569-1993
1873-5010
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.jcf.2011.08.005
Volume 11
Issue 1
Start page 49
End page 52
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Aim: To evaluate changes in prevalence of an epidemicstrain of Pseudomonas aeruginosa (AES-1, Australianepidemicstrain, type 1) in a paediatric cysticfibrosis (CF) centre practising cohort segregation, to describe the patients' clinical characteristics at acquisition and observe mortality rates.
Methods: Cohort segregation was introduced in our paediatric CF clinic January 2000. The prevalence of AES-1 was analysed in 1999, 2002 and 2007. Age at acquisition, lung function, presence of bronchiectasis, hospitalisations, prior P. aeruginosa infection and mortality rates were collected. AES-1 infection was determined by pulse-field-gel-electrophoresis (PFGE) on airway specimen cultures taken three monthly.
Results: The prevalence of AES-1 declined from 21% in 1999 to 14% in 2002 (risk difference 7% (95% CI 1,13) p = 0.0256) and to 6% in 2007 (risk difference 8% (95% CI 3,13) p = 0.0018). New acquisitions after the introduction of cohort segregation were uncommon (10 by 2002 and another 7 by 2007) with a declining incidence of 3.3 cases/year (1999 to 2002) compared to 1.4 cases/year (2002 to 2007). Twenty-two of 32 (69%) deaths between 1999 and 2007 occurred in patients infected with AES-1.
Conclusion: Cohort segregation has been associated with reductions in the prevalence of AES-1 in our CF clinic. Mortality was higher in patients infected with AES-1 than other organisms.
Keyword Pseudomonas aeruginosa
Bronchiectasis
Bacterial infections
Infection control
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Available online 9 September 2011. Published under Short Communications.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Wed, 22 Feb 2012, 10:35:04 EST by Martina Franke on behalf of Child Health Research Centre