Structure-activity studies on alpha-conotoxins

Muttenthaler, Markus, Akondi, Kalyana B. and Alewood, Paul F. (2011) Structure-activity studies on alpha-conotoxins. Current Pharmaceutical Design, 17 38: 4226-4241.

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Name Description MIMEType Size Downloads
Author Muttenthaler, Markus
Akondi, Kalyana B.
Alewood, Paul F.
Title Structure-activity studies on alpha-conotoxins
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1381-6128
Publication date 2011-12
Sub-type Critical review of research, literature review, critical commentary
Volume 17
Issue 38
Start page 4226
End page 4241
Total pages 16
Place of publication Bussum, The Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Formatted abstract
Conotoxins are small bioactive highly structured peptides from the venom of marine cone snails (genus Conus). Over the past 50 million years these molluscs have developed a complex venom cocktail for each species that is comprised of 100-2000 distinct cysteine- rich peptides for prey capture and defence. This review focuses on an important and well-studied class of conotoxins, the α- conotoxins. These α-conotoxins are potent and selective antagonists of various subtypes of the nicotinic acetylcholine receptors (nAChRs). Key structure-activity relationship studies are presented to illustrate the common motifs, structural features and pharmacophores that define this interesting peptide class. Additionally, their synthesis, chemical modifications, the development of more selective and stable analogues and their therapeutic potential are discussed.
Keyword Alpha-conotoxins
Peptide synthesis
Post-translational modifications
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
ERA White List Items
Institute for Molecular Bioscience - Publications
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