Nutrapharmacology of tocotrienols for metabolic syndrome

Weng-Yew, Wong and Brown, Lindsay (2011) Nutrapharmacology of tocotrienols for metabolic syndrome. Current Pharmaceutical Design, 17 21: 2206-2214. doi:10.2174/138161211796957445

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Author Weng-Yew, Wong
Brown, Lindsay
Title Nutrapharmacology of tocotrienols for metabolic syndrome
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1381-6128
Publication date 2011-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/138161211796957445
Volume 17
Issue 21
Start page 2206
End page 2214
Total pages 9
Place of publication Bentham Science Publishers
Publisher Bussum, Netherlands
Collection year 2012
Language eng
Abstract Metabolic syndrome is defined as a set of health risk factors that are associated with an increased chance of cardiovascular diseases and type 2 diabetes. These include abdominal obesity, hyperglycemia, impaired glucose tolerance, dyslipidemia, and hypertension. Interventions in metabolic syndrome include lifestyle interventions such as a healthy diet using functional foods together with increased physical activity to induce weight loss as the first aim of treatment. Nutraceuticals such as tocotrienols and tocopherols as members of the vitamin E family may be more targeted interventions. This review evaluates the effects of tocotrienols on the risk factors of metabolic syndrome using data from human, animal and in vitro studies. Tocotrienols improved lipid profiles and reduced atherosclerotic lesions, decreased blood glucose and glycated hemoglobin concentrations, normalized blood pressure, and inhibited adipogenesis. The differences in responses between tocopherols and tocotrienols in preventing obesity, diabetes, hypertension, artherosclerosis, ischemia, and inflammation suggest that different receptors or signaling mechanisms may be involved.
Keyword Metabolic syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
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