Evolutionary origin of stretch-activated ion channels

Martinac, Boris and Kloda, Anna (2011). Evolutionary origin of stretch-activated ion channels. In Peter Kohl, Frederick Sachs and Michael R. Franz (Ed.), Cardiac mechano-electric coupling and arrhythmias 2nd ed. (pp. 3-10) Oxford, United Kingdom: Oxford University Press.

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Name Description MIMEType Size Downloads
Author Martinac, Boris
Kloda, Anna
Title of chapter Evolutionary origin of stretch-activated ion channels
Title of book Cardiac mechano-electric coupling and arrhythmias
Place of Publication Oxford, United Kingdom
Publisher Oxford University Press
Publication Year 2011
Sub-type Critical review of research, literature review, critical commentary
Edition 2nd
ISBN 9780199570164
Editor Peter Kohl
Frederick Sachs
Michael R. Franz
Chapter number 1
Start page 3
End page 10
Total pages 8
Total chapters 65
Collection year 2012
Language eng
Formatted Abstract/Summary
Stretch-activated channels (SAC) present the major type of mechana- sensitive channels (MSC) found in living cells. They convert mechanical stimuli acting upon membranes of biological cells into electrical or chemical signals in mechano-sensory transduction
processes ranging from turgor control in bacteria and plant cells to hearing, touch, renal tubular function and blood pressure regulation in mammals. In the evolution of different life forms on Earth these ion channels probably represent the oldest sensory
transduction molecules that evolved as primary signalling elements in mecbano-sensory physiology of living organisms. The concept of ion channels gated by mechanical stimuli arose originally from studies of specialized mechano-sensory neurons. Their discovery
in embryonic chick skeletal muscle and in frog muscle some 25 years ago confirmed this concept and, furthermore, it demonstrated their existence in many non-specialized cell types. Instrumental for the discovery of SAC was the invention of the patch-clamp technique, which allowed the first direct measurements of single mechano-sensitive channel currents in a variety of non-specialized cells. Although once considered an artefact of the patch-clamp recording, mechano-sensitive ion channels attracted revived interest after cloning and structural characterization of SAC in bacteria and Archaea and cloning of several SAC implicated in mechano-transduction processes in invertebrates
and vertebrates. Currently, mechano-sensitive channel proteins are at the focus of structural, spectroscopic, computational and functional studies aiming to understand the molecular basis of mechano-sensory transduction in living cells. [Background]
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Rev. ed. of: 'Cardiac mechano-electric feedback and arrhythmias : from pipette to patient' published 2005

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