Design and implementation of therapeutic ultrasound generating circuit for dental tissue formation and tooth-root healing

Ang, Woon Tiong, Scurtescu, Cristian, Hoy, Wing, El-Bialy, Tarek, Tsui, Ying Yin and Chen, Jie (2010) Design and implementation of therapeutic ultrasound generating circuit for dental tissue formation and tooth-root healing. IEEE Transactions On Biomedical Circuits and Systems, 4 1: 49-61. doi:10.1109/TBCAS.2009.2034635


Author Ang, Woon Tiong
Scurtescu, Cristian
Hoy, Wing
El-Bialy, Tarek
Tsui, Ying Yin
Chen, Jie
Title Design and implementation of therapeutic ultrasound generating circuit for dental tissue formation and tooth-root healing
Journal name IEEE Transactions On Biomedical Circuits and Systems   Check publisher's open access policy
ISSN 1932-4545
1940-9990
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1109/TBCAS.2009.2034635
Volume 4
Issue 1
Start page 49
End page 61
Total pages 13
Place of publication Piscataway, NJ, United States
Publisher IEEE
Language eng
Formatted abstract
Biological tissue healing has recently attracted a great deal of research interest in various medical fields. Trauma to teeth, deep and root caries, and orthodontic treatment can all lead to various degrees of root resorption. In our previous study, we showed that low-intensity pulsed ultrasound (LIPUS) enhances the growth of lower incisor apices and accelerates their rate of eruption in rabbits by inducing dental tissue growth. We also performed clinical studies and demonstrated that LIPUS facilitates the healing of orthodontically induced teeth-root resorption in humans. However, the available LIPUS devices are too large to be used comfortably inside the mouth. In this paper, the design and implementation of a low-power LIPUS generator is presented. The generator is the core of the final intraoral device for preventing tooth root loss and enhancing tooth root tissue healing. The generator consists of a power-supply subsystem, an ultrasonic transducer, an impedance-matching circuit, and an integrated circuit composed of a digital controller circuitry and the associated driver circuit. Most of our efforts focus on the design of the impedance-matching circuit and the integrated system-on-chip circuit. The chip was designed and fabricated using 0.8- um high-voltage technology from Dalsa Semiconductor, Inc. The power supply subsystem and its impedance-matching network are implemented using discrete components. The LIPUS generator was tested and verified to function as designed and is capable of producing ultrasound power up to 100 mW in the vicinity of the transducer's resonance frequency at 1.5 MHz. The power efficiency of the circuitry, excluding the power supply subsystem, is estimated at 70%. The final products will be tailored to the exact size of teeth or biological tissue, which is needed to be used for stimulating dental tissue (dentine and cementum) healing.
Keyword Dental tissue formation
Dental traumatology
Low intensity pulsed ultrasound (LIPUS)
System-on-a-chip design
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article # 5356185

Document type: Journal Article
Sub-type: Article (original research)
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