Exercise capacity and muscle strength in patients with cirrhosis

Jones, Jacqueline C., Coombes, Jeff S. and Macdonald, Graeme A. (2012) Exercise capacity and muscle strength in patients with cirrhosis. Liver Transplantation, 18 2: 146-151. doi:10.1002/lt.22472


Author Jones, Jacqueline C.
Coombes, Jeff S.
Macdonald, Graeme A.
Title Exercise capacity and muscle strength in patients with cirrhosis
Journal name Liver Transplantation   Check publisher's open access policy
ISSN 1527-6473
1527-6465
Publication date 2012-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/lt.22472
Volume 18
Issue 2
Start page 146
End page 151
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley and Sons
Collection year 2013
Language eng
Formatted abstract Exercise capacity and muscle strength are predictors of outcome in a number of clinical populations. Advanced liver disease is a catabolic state, and patients often have muscle wasting. However, the relationships between exercise capacity, strength, and outcomes for patients undergoing liver transplantation are poorly understood. Thirteen studies have examined the association between these parameters in patients with cirrhosis, and they have found a significant reduction in the exercise capacity and muscle strength of patients with cirrhosis versus healthy controls. These impairments appear to be independent of the etiology of cirrhosis, but the data are equivocal with respect to their association with disease severity. Two studies reported a significant and independent association between pretransplant exercise capacity and posttransplant survival. Another 2 studies found that exercise training was well tolerated in patients with cirrhosis and resulted in improvements in exercise capacity (both studies) and muscle mass (1 study). These data are provocative and suggest that measuring and improving the exercise capacity and muscle strength of patients with cirrhosis who are awaiting liver transplantation could potentially improve outcomes.
Keyword Exercise
Hospital Admissions
Liver cirrhosis
Liver Transplantation
Muscle Strength
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication details: 18:146-151, 2012, but 2011 copyright. Accepted November 2011. Jacqueline C. Jones affiliation is listed as: (1)School of Human Movement Studies and the (2)NHMRC Centre of Clinical Research Excellence in Cardiovascular, Metabolic and Kidney Disease, The University of Queensland but I could not find her on the drop down list.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Human Movement Studies Publications
School of Medicine Publications
 
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Created: Fri, 17 Feb 2012, 18:34:03 EST by Deborah Noon on behalf of School of Human Movement Studies