Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency

Harms, Lauren R., Cowin, Gary, Eyles, Darryl W., Kurniawan, Nyoman D., McGrath, John J. and Burne, Thomas H. J. (2012) Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency. Behavioural Brain Research, 230 1: 125-131. doi:10.1016/j.bbr.2012.02.007

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ267771_OA.pdf Full text (open access) application/pdf 58.45KB 1

Author Harms, Lauren R.
Cowin, Gary
Eyles, Darryl W.
Kurniawan, Nyoman D.
McGrath, John J.
Burne, Thomas H. J.
Title Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
1872-7549
Publication date 2012-04-21
Sub-type Article (original research)
DOI 10.1016/j.bbr.2012.02.007
Open Access Status File (Author Post-print)
Volume 230
Issue 1
Start page 125
End page 131
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2013
Language eng
Formatted abstract
Evidence from epidemiology suggests that developmental vitamin D (DVD) deficiency is associated with an increased risk of schizophrenia. DVD deficiency in rats is associated with altered brain morphology and enhanced hyperlocomotion in response to MK-801 and amphetamine. The aim of this study was to determine if similar phenotypes were associated with DVD deficiency in two strains of mice (C57BL/6J, 129/X1SvJ). Brains from neonatal (P0) and adult (P70) mice were imaged using MRI and the volumes of the cerebrum, hippocampus, striatum, septum, cortex and ventricles measured, as well as the widths of white matter tracts. Locomotor sensitivity to 5 mg/kg d-amphetamine, 0.5 mg/kg MK-801 or saline was examined in a separate group of mice in an open field. DVD deficiency altered brain morphology in C57BL6/J mice, such that C57BL/6J female DVD-deficient neonatal mice had a smaller hippocampus compared to female controls. In addition, adult C57BL/6J male DVD-deficient mice had smaller lateral ventricles compared to controls, which may have been compressed by the enlarged striatum seen in these DVD-deficient mice. However, in contrast to the behavioural phenotypes found in DVD-deficient rats, there was no significant effect of maternal diet on amphetamine or MK-801-induced locomotion in either strain. These data indicate that not only species, but also strain of mouse, moderates the impact of DVD deficiency on neuroanatomical and behavioural phenotypes in rodent animal models.

Highlights: ► Epidemiological evidence suggests that DVD deficiency leads to an increased risk of schizophrenia. ► Neonate C57BL/6J female DVD-deficient mice had a smaller hippocampus compared to controls. ► Adult C57BL/6J male DVD-deficient mice had smaller lateral ventricles compared to controls. ► There was no effect of maternal diet on psychomimetic-induced locomotion.
Keyword Vitamin D
Brain development
Schizophrenia
Animal model
Magnetic resonance imaging
C57BL/6J
129X1/SvJ
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 16 Feb 2012, 11:28:57 EST by Sandrine Ducrot on behalf of Queensland Brain Institute